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A1527

Sigma-Aldrich

Adrenocorticotropic Hormone Fragment 7-38 human

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C167H257N47O46
CAS Number:
68563-24-6
Molecular Weight:
3659.11
MDL number:
MFCD00081282
UNSPSC Code:
51111800
NACRES:
NA.77

sterility

non-sterile

Quality Level

200

assay

≥97% (HPLC)

form

powder

UniProt accession no.

P01189

storage temp.

−20°C

Gene Information

human ... POMC(5443)

Amino Acid Sequence

Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu

Application

Adrenocorticotropic hormone fragment 7-38 human has been used as astandard in external calibration for mass spectrometry.

Biochem/physiol Actions

Adrenocorticotropic hormone (ACTH) is a polypeptide hormone thatstimulates adrenocortical activity. It is produced by the prohormoneproopiomelanocortin (POMC), which is synthesized in the corticotroph andmelanotroph cells found in the intermediate and anterior lobe of the pituitarygland and the arcuate nucleus of the hypothalamus. ACTH is also synthesized inthe skin. It plays a role in controlling steroidogenesis in the adrenal glandand prevents reactive oxygen species (ROS)-induced cell toxicity. Higher levelsof ACTH lead to skin hyperpigmentation due to the hyperstimulation ofmelanocytes, characteristic of primary adrenal insufficiency (PAI). Deficiencyof ACTH synthesis, receptors, or signaling is associated with adrenalinsufficiency.

Other Notes

ACTH fragment that is a potent inhibitor of ACTH-stimulated adenylate cyclase.
Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Juan Castillo et al.
The Journal of endocrinology, 196(2), 313-322 (2008-02-07)
Steroidogenic acute regulatory protein (StAR) transfers cholesterol over the inner mitochondrial membrane. In mammals, StAR controls this rate-limiting step of steroidogenesis, but its expression and regulation has not been well explored in fish. The present work investigates StAR mRNA expression
V L Clifton et al.
The Journal of clinical endocrinology and metabolism, 81(4), 1406-1410 (1996-04-01)
During human pregnancy, ACTH is produced by both the placenta and fetal pituitary. ACTH has been shown to cause vasodilatation in the adrenal cortex in vitro. In this context we have investigated the vasoactive effects of ACTH in the human
Kristin L Schreiber et al.
Stress (Amsterdam, Netherlands), 8(3), 185-190 (2005-12-06)
Exposure to stress is associated with susceptibility to disease and one stress mediator, norepinephrine, has been reported to enhance the adherence of enterohemorrhagic Escherichia coli O157:H7 (EHEC) to the colonic mucosa. We tested the hypothesis that adrenocorticotropic hormone (ACTH) and
L K Malendowicz et al.
The Journal of steroid biochemistry and molecular biology, 67(2), 149-152 (1999-01-07)
Corticotropin-inhibiting peptide (CIP), the 7-38 fragment of human ACTH(1-39), is known to act as an antagonist of ACTH receptors. Accordingly, CIP has been found to inhibit ACTH-stimulated glucocorticoid secretion of dispersed rat adrenocortical cells, without per se affecting the basal
L K Malendowicz et al.
The Journal of steroid biochemistry and molecular biology, 70(4-6), 185-188 (2000-01-06)
Orexins-A and B are two novel hypothalamic peptides, which, like leptin and neuropeptide-Y (NPY), are involved in the central regulation of feeding. Since leptin and NPY were found to modulate adrenal function, we have examined whether orexins are able to
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