73914

Sphingosine 1-phosphate

≥98.0% (TLC)

• Synonym(s): (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate, D-erythro-Sphingosine 1-phosphate
• Empirical Formula (Hill Notation): C₁₈H₃₈NO₅P
• CAS Number: 26993-30-6
• Molecular Weight: 379.47
• MDL number: MFCD00270077
• UNSPSC Code: 12352211
• PubChem Substance ID: 329765332
• NACRES: NA.85

Properties

• assay: ≥98.0% (TLC)
• form: powder
• composition: carbon content, 56.97% ; hydrogen content, 10.09% ; nitrogen content, 3.69%
• lipid type: sphingolipids
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O
• InChI: 1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
• InChI key: DUYSYHSSBDVJSM-KRWOKUGFSA-N

Description

Application

Repurposing Siponimod for osteoporosis: A study highlighted the potential of Siponimod, an S1P receptor modulator originally developed for multiple sclerosis, to treat osteoporosis by influencing Sphingosine 1-phosphate pathways (Hu et al., 2024).

Sphingosine-1-phosphate in ocular health: Research demonstrated that a selective agonist for Sphingosine-1-phosphate receptor 1/5 could mitigate ocular vascular pathologies, suggesting therapeutic potentials in eye disease management, it is also responsible for regulating various intracellular processes, including cell survival, differentiation, and proliferation (Nakamura et al., 2024).

Targeting diabetic kidney disease: The study investigated how Plantaginis Semen, through the sphingosine kinase 1/Sphingosine-1-phosphate pathway, could ameliorate diabetic kidney disease, underscoring the pathways role in metabolic health (Lan et al., 2024).

Advancements in neurodegenerative disease treatments: A review focused on the development of small-molecule modulators targeting Sphingosine-1-phosphate receptors, presenting new directions in treating neurodegenerative diseases (Sankar Kar et al., 2024).

Biochem/physiol Actions

A lipid second messenger that binds to S1P₁ and S1P₃ receptors. Mobilizes intracellular Ca²⁺ stores and decreases cellular cAMP. Activates phospholipase D. S1P stimulates the migration of endothelial cells but inhibits the migration of other cell types. Induces angiogenesis.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable