485A-1

ATRX Rabbit Polyclonal Antibody

• Synonym(s): ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein (XNP)
• UNSPSC Code: 41116161

Properties

• biological source: rabbit blood
• Quality Level: 100; 500
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• description: For In Vitro Diagnostic Use in Select Regions
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL (concentrate (485A-14)); vial of 0.1 mL (concentrate (485A-14-RUO) Research Use Only); vial of 0.5 mL (concentrate (485A-15)); vial of 1.0 mL (concentrate (485A-16)); vial of 1.0 mL (concentrate (485A-16-RUO) Research Use Only); vial of 1.0 mL (concentrate (485A-17-RUO) Research Use Only); vial of 1.0 mL (pre-dilute ready-to-use (485A-17)); vial of 7.0 mL (concentrate (485A-18-RUO) Research Use Only); vial of 7.0 mL (pre-dilute ready-to-use (485A-18))
• manufacturer/tradename: Cell Marque^™
• technique(s): immunocytochemistry: suitable (formalin-fixed, paraffin-embedded sections 1:50-1:50 (concentrated))
• isotype: IgG
• control: astrocytoma, brain, glioblastoma, oligodendroglioma
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: nuclear

Description

General description

Diffuse gliomas are classified based on histological and molecular features to achieve an integrated diagnosis. Molecular diagnostic markers include IDH mutation, 1p/19q co-deletion, and TP53 mutation. ATRX is a chromatin remodeling protein and its mutation status may be used as a molecular diagnostic marker within the diff use glioma classification algorithm. Anti-ATRX is used to identify mutant ATRX by a loss of ATRX expression in neoplastic cells when compared with internal positive controls (endothelial cells, glia, and neurons). Grade II/III astrocytoma classification includes IDH mutant, ATRX mutant, and 1p/19q retention, while grade II/III oligodendroglioma includes IDH mutant, ATRX wildtype, and 1p/19q co-deletion; p53 expression may also serve as an aid in diagnosis. ATRX mutation is frequently, but not always, mutually exclusive with 1p/19q co-deletion.

Quality

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 2