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17928

Sigma-Aldrich

O-Methyl-O′-succinylpolyethylene glycol 2′000

Synonym(s):

Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 2′000, Polyethylene glycol 2′000 monomethyl ether succinate

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About This Item

Linear Formula:
CH3O(CH2CH2O)nCOCH2CH2COOH
CAS Number:
31961-02-1
MDL number:
MFCD00284260
UNSPSC Code:
51171641
NACRES:
NA.26

form

powder

mol wt

Mr ~2100

mp

50-53 °C

Ω-end

carboxylic acid

α-end

methoxy

storage temp.

−20°C

Application

Polyethylene glycol 2000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.

Biochem/physiol Actions

O-Methyl-O′-succinylpolyethylene glycol 2′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Antitumor effect of liposomal histone deacetylase inhibitor-lipid conjugates in vitro.
Hattori Y, Nagaoka Y, Kubo M, et al.
Chemical & Pharmaceutical Bulletin, 59, 1389-1392 (2011)
Gulam Mustafa Hasan et al.
Journal of parasitology research, 2011, 120462-120462 (2011-07-21)
We have examined the effect of stearylamine (SA) in liposomes on the viability of Plasmodium falciparum in culture by studying the inhibition of incorporation of [(3)H]-hypoxanthine in the nucleic acid of parasites. Stearylamine in liposomes significantly inhibits the growth of
Ayman El-Sayed et al.
Journal of pharmaceutical sciences, 101(2), 879-882 (2011-11-17)
We previously reported on a stearylated INF7 peptide (str-INF7), which enhances the endosomal escape of an octaarginine (R8)-modified liposomal particle encapsulating plasmid DNA (pDNA) in a fusion-independent manner. This study examined whether this peptide derivative enhanced the endosomal escape and
Peptide/protein-polymer conjugates: synthetic strategies and design concepts.
Gauthier MA, Klok HA.
Chemical Communications (Cambridge, England), 21, 2591-2611 (2008)
Sabrina Hoffmann et al.
Immunology letters, 136(1), 13-20 (2010-11-30)
T-cell recognition of peptide-MHC complexes on APCs requires cell-cell interactions. The molecular events leading to T-cell activation have been extensively investigated, but the underlying physical binding forces between T-cells and APCs are largely unknown. We used single cell force spectroscopy
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