209198

Copper(II) sulfate pentahydrate

ACS reagent, ≥98.0%

• Synonym(s): Cupric sulfate pentahydrate, Sulfuric acid, copper(II) salt (1:1) pentahydrate
• Linear Formula: CuSO₄ · 5H₂O
• CAS Number: 7758-99-8
• Molecular Weight: 249.69
• EC Number: 231-847-6
• MDL number: MFCD00149681
• UNSPSC Code: 12352302
• PubChem Substance ID: 329752057
• NACRES: NA.21

Properties

• grade: ACS reagent
• Quality Level: 200
• vapor pressure: 7.3 mmHg ( 25 °C)
• assay: ≥98.0%; 98.0-102.0% (ACS specification)
• form: crystals
• reaction suitability: reaction type: click chemistry; reagent type: catalyst; core: copper
• pH: 3.5-4.5 (20 °C, 50 g/L)
• mp: 110 °C (dec.) (lit.)
• anion traces: chloride (Cl^-): ≤0.001%
• cation traces: Ca: ≤0.005%; Fe: ≤0.003%; K: ≤0.01%; Na: ≤0.02%; Ni: ≤0.005%
• SMILES string: O.O.O.O.O.[Cu++].[O-]S([O-])(=O)=O
• InChI: 1S/Cu.H2O4S.5H2O/c;1-5(2,3)4;;;;;/h;(H2,1,2,3,4);5*1H2/q+2;;;;;;/p-2
• InChI key: JZCCFEFSEZPSOG-UHFFFAOYSA-L

Description

General description

Copper(II) sulfate pentahydrate is a Lewis acid catalyst commonly used to promote acid-catalyzed organic transformations. It can also act as an effective redox catalyst in combination with other mixed oxidizing agents.

Application

Copper(II) sulfate pentahydrate can be used as a catalyst:      

• In acetylation of alcohols and phenols in the presence of acetic anhydride.      
• To synthesize various ynamides via intramolecular coupling of amides with alkynyl bromides.

It can also be used as a template in the synthesis of copper(II) ion-imprinted polymers using vinylpyridine and methacrylic acid as functional monomers. This polymer is used to quantify Cu²⁺ ion by using flame atomic absorption spectroscopy.

Features and Benefits

CuSO₄.5H₂O is an inexpensive, safe catalyst to be used in various organic transformations. It can also be recovered and reused in another reaction.

Safety Information

• pictograms: GHS05,GHS07,GHS09
• signalword: Danger
• hcodes: H302,H318,H410
• pcodes: P264 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P391
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1
• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable