Titanium(IV) chloride

ReagentPlus®, 99.9% trace metals basis

TTC, Titanium tetrachloride
Linear Formula:
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

vapor pressure

50 mmHg ( 55 °C)
9.6 mmHg ( 20 °C)

product line



99.9% trace metals basis



reaction suitability

reagent type: catalyst
core: titanium


135-136 °C (lit.)


−25 °C (lit.)


1.73 g/mL at 20 °C (lit.)

SMILES string




InChI key


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General description

Titanium(IV) chloride participates in the Baylis-Hillman reaction of arylaldehydes with methyl vinyl ketone. Neutral solutions of TiCl4 having a pH in the range of 2.5 to 6.0 (prepared by the addition of magnesium oxide as a base) have been used for the synthesis of nanosized titanium dioxide.


Along with sodium borohydride, it forms an effective reagent for the reduction of:
  • carboxylic acid and acyl chloride to alcohols
  • carboxamides, oximes and lactams to amines
  • sulfoxides to sulfides
Titanium(IV) chloride (TiCl4) has been used as a precursor for the synthesis of Ag-TiO2@polyethylene glycol (PEG) nanoparticles. TiCl4 may also be used as one of the constituents to synthesize TiO2/Al2O3 binary oxide materials and N-(10-oxo-vinylanthracen-9-(10H)-ylidene)cyanamide.
Activates pyrrolidines for improved conversion, via a modified Bouveault reaction, to the corresponding α,α-dimethylamines.


200 g in Sure/Seal™
1.5 kg in Sure/Seal™

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC


CorrosionSkull and crossbones

Signal Word


Hazard Statements


Acute Tox. 1 Inhalation - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

Target Organs

Respiratory system

Supp Hazards



6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

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  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is Product 208566, Titanium(IV) chloride, soluble in?

    Per the chemicals encyclopedia published by the Royal Society of Chemistry, Titanium(IV) Chloride is soluble in cold water and alcohol.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Gaofei Xiao et al.
Journal of environmental sciences (China), 60, 14-23 (2017-10-17)
Reduction of some functional groups with titanium (IV) chloride/sodium borohydride.
Kano S, et al.
Synthesis, 1980(09), 695-697 (1980)
Scalable hybrid chemical manufacture to photothermal therapy: PEG-capped phototransducers
Byeon, Jeong Hoon
Scientific Reports, 6 (2016)
Poly [N-(10-oxo-2-vinylanthracen-9(10H)-ylidene) cyanamide] as a novel cathode material for li-organic batteries.
Schmidt D, et al.
Journal of Polymer Science Part A: Polymer Chemistry, 53(21), 2517-2523 (2015)
Influence of the sol-gel preparation method on the photocatalytic NO oxidation performance of TiO2/Al2O3 binary oxides.
Polat M, et al.
Catalysis Today, 241, 25-32 (2015)

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