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SMB01354

Sigma-Aldrich

Losartan carboxylic acid

≥95% (HPLC)

Synonym(s):

EXP3174, 2-Butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid, E-3174, EXP 3174, EXP-3174

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About This Item

Empirical Formula (Hill Notation):
C22H21ClN6O2
CAS Number:
124750-92-1
Molecular Weight:
436.89
MDL number:
MFCD00871928
UNSPSC Code:
12352106
NACRES:
NA.21

Quality Level

100

assay

≥95% (HPLC)

form

solid

shipped in

wet ice

InChI

1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)

InChI key

ZEUXAIYYDDCIRX-UHFFFAOYSA-N

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General description

Losartan Carboxylic Acid (E-3174) is an active carboxylic acid metabolite of Losartan. Losartan Carboxylic Acid is a potent and selective angiotensin II receptor type 1 (AT1) antagonist.

Application

Metabolomics research

Other Notes

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Lact. - Repr. 1B - Skin Sens. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Eleni Karatza et al.
Basic & clinical pharmacology & toxicology, 126(3), 193-202 (2019-09-13)
Losartan presents multiple peaks in the concentration-time profile. This characteristic can be attributed to gastric emptying, which is known to significantly affect the disposition of highly soluble and permeable compounds. The aim of this study was to develop a population
A Gromotowicz-Poplawska et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 70(3) (2019-10-01)
The aim of the study was to evaluate the effect of an active metabolite of losartan - EXP3174 - on a performed venous thrombus in hypertensive rat. The contribution of coagulation and fibrinolytic systems as well as platelets in the
L L Chang et al.
Journal of medicinal chemistry, 36(17), 2558-2568 (1993-08-20)
A series of 2,4-dihydro-2,4,5-trisubstituted-3H-1,2,4-triazol-3-ones was prepared via several synthetic routes and evaluated as AII receptor antagonists in vitro and in vivo. The preferred compounds contained a [2'-(5-tetrazolyl)biphenyl-4-yl]methyl side chain at N4 and an n-butyl group at C5. A number of

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