SMB00929

5′-Hydroxy carvedilol

≥95% (HPLC)

• Synonym(s): 5′-Hydroxy carvedilol, 3-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-4-methoxyphenol, 5′-Hydroxyphenyl carvedilol, 5′-Hydroxyphenylcarvedilol, 5′-OH carvedilol, 5-Hydroxycarvedilol, 5OHC, BM-140830, Carvedilol metabolite M5
• Empirical Formula (Hill Notation): C₂₄H₂₆N₂O₅
• CAS Number: 142227-51-8
• Molecular Weight: 422.47
• UNSPSC Code: 12352200
• NACRES: NA.25

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• color: off-white
• solubility: DMSO: soluble, clear, colorless
• storage temp.: 2-8°C
• InChI: 1S/C24H26N2O5/c1-29-21-10-9-16(27)13-23(21)30-12-11-25-14-17(28)15-31-22-8-4-7-20-24(22)18-5-2-3-6-19(18)26-20/h2-10,13,17,25-28H,11-12,14-15H2,1H3
• InChI key: PVUVZUBTCLBJMT-UHFFFAOYSA-N

Description

General description

Carvedilol is a β- and α1-adrenoreceptor blocker for the treatment of hypertension and congestive heart failure (CHF). The drug is metabolized by CYP2D6 (to 4′-OH and 5′-OH), CYP2C9 (to O-desmethyl), CYP1A2 (to 8-OH). It is also oxidized to 1-OH carvedilol, but the enzyme involved is not yet clear. These metabolites are useful markers for studying and monitoring the activities of cytochrome metabolizing enzymes. M4 metabolite (4′-OH), but not M2 or M5, is most likely to contribute to total β-adrenoceptor blocking activity due to its higher potency.

Other Notes

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Safety Information

• pictograms: GHS08,GHS09
• signalword: Warning
• hcodes: H373,H411
• pcodes: P260 - P273 - P314 - P391 - P501
• Hazard Classifications: Aquatic Chronic 2 - STOT RE 2
• target_organs: Liver,spleen,Adrenal gland,Uterus (including cervix)
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable