PHR1919

Chlorzoxazone

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Chlorzoxazone, CLZ, 5-Chloro-2(3H)-benzoxazolone, 5-Chloro-2-hydroxybenzoxazole
• Empirical Formula (Hill Notation): C₇H₄ClNO₂
• CAS Number: 95-25-0
• Molecular Weight: 169.57
• EC Number: 222-649-0
• MDL number: MFCD00005717
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to USP 1130505
• API family: chlorzoxazone
• CofA: current certificate can be downloaded
• packaging: pkg of 500 mg
• mp: 191-192 °C (lit.)
• application(s): pharmaceutical
• format: neat
• storage temp.: 2-30°C
• SMILES string: Clc1ccc2OC(=O)Nc2c1
• InChI: 1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
• InChI key: TZFWDZFKRBELIQ-UHFFFAOYSA-N
• Gene Information: human ... KCNN4(3783)

Description

General description

Chlorzoxazone is a centrally active muscle relaxant used to treat painful muscle spasms linked to musculoskeletal disorders, such as fibrositis, bursitis, myositis, spondylitis, etc.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Chlorzoxazone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography technique, spectrophotometry and fluorescence spectroscopy.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Chlorzoxazone is a skeletal muscle relaxant.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB0913 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable