PHR1498

Sulfacetamide

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Sulfacetamide, N-(4-Aminobenzenesulfonyl)acetamide, N-(4-Aminophenylsulfonyl)acetamide, N¹-Acetylsulfanilamide
• Empirical Formula (Hill Notation): C₈H₁₀N₂O₃S
• CAS Number: 144-80-9
• Molecular Weight: 214.24
• Beilstein/REAXYS Number: 981718
• EC Number: 205-640-6
• MDL number: MFCD00066501
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823419
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to USP 1623808
• API family: sulfacetamide
• CofA: current certificate can be downloaded
• packaging: pkg of 1 g
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: CC(=O)NS(=O)(=O)c1ccc(N)cc1
• InChI: 1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
• InChI key: SKIVFJLNDNKQPD-UHFFFAOYSA-N

Description

General description

Sulfacetamide is commonly used in ophthalmic preparations, to treat different ocular infections such as cornela ulcers and conjunctivitis. It is generally formulated as a sodium salt and used as 10-30% w/v ophthalmic solution.

Application

Sulfacetamide may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using column chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA3046 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H317,H335
• pcodes: P261 - P271 - P272 - P280 - P302 + P352 - P304 + P340 + P312
• Hazard Classifications: Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable