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80073

Supelco

α-Hydroxymetoprolol

analytical standard

Synonym(s):

3-[4-(1-Hydroxy-2-methoxyethyl)phenoxy]-1-isopropylamino-2-propanol, 4-{2-Hydroxy-3-[(1-methylethyl)amino]propoxy}-α-(methoxymethyl)-benzenemethanol

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About This Item

Empirical Formula (Hill Notation):
C15H25NO4
CAS Number:
56392-16-6
Molecular Weight:
283.36
Beilstein/REAXYS Number:
6571082
MDL number:
MFCD00871829
UNSPSC Code:
41116107
PubChem Substance ID:
329768718
NACRES:
NA.24

grade

analytical standard

Quality Level

100

assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

68-74 °C

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

OC(CNC(C)C)COC1=CC=C(C(O)COC)C=C1

InChI

1S/C15H25NO4/c1-11(2)16-8-13(17)9-20-14-6-4-12(5-7-14)15(18)10-19-3/h4-7,11,13,15-18H,8-10H2,1-3H3

InChI key

OFRYBPCSEMMZHR-UHFFFAOYSA-N

Related Categories

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCD2430
BCBV0619
BCBM2433V
BCBM2433

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D R Sohn et al.
Therapeutic drug monitoring, 14(3), 184-189 (1992-06-01)
We examined the utility of the postdose 3-h plasma metabolic ratio (MR) as a phenotyping method for assessing genetically determined debrisoquine-type oxidation polymorphism after an oral dose of 100 mg of metoprolol tartrate administered to 402 unrelated, healthy, and native
B Mistry et al.
Journal of pharmaceutical and biomedical analysis, 16(6), 1041-1049 (1998-04-21)
A reverse-phase High Performance Liquid Chromatographic (HPLC) method was developed for the analysis of metoprolol in the large number of human plasma samples obtained in in vitro-in vivo correlations (IVIVC) and bioavailability studies of extended release formulations of metoprolol tartrate.
Ksenia Goryachkina et al.
European journal of clinical pharmacology, 64(3), 275-282 (2007-11-29)
To investigate the influence of paroxetine on metoprolol concentrations and its effect in patients treated for acute myocardial infarction (AMI) who are routinely given paroxetine as a co-treatment of depression. We recruited 17 depressed AMI patients who received metoprolol as
Carrie A Morris et al.
Antimicrobial agents and chemotherapy, 58(10), 5900-5908 (2014-07-30)
The objectives of this study were to characterize any drug-drug interaction between the antimalarial Pyramax (pyronaridine-artesunate [PA]) and the CYP2D6 probe substrate metoprolol and to assess the safety of 60-day or 90-day PA redosing, particularly with regard to liver biochemistry
H Shimizu et al.
Arzneimittel-Forschung, 42(6), 802-806 (1992-06-01)
The maximum plasma concentrations (Cmax) after oral administration of 120 mg tablets of slow-release metoprolol (CAS 37350-58-6) to 75 Japanese healthy male volunteers and 15 arrhythmic patients were measured. Extensive and poor metabolizers after oral administrations of slow-release metoprolol tablets
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