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53787

Supelco

Carazolol

analytical standard

Synonym(s):

1-(Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol, 4-(2-Hydroxy-3-isopropylamino-propoxy)carbazole

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About This Item

Empirical Formula (Hill Notation):
C18H22N2O2
CAS Number:
57775-29-8
Molecular Weight:
298.38
Beilstein/REAXYS Number:
3620576
EC Number:
260-945-1
MDL number:
MFCD00864588
UNSPSC Code:
41116107
PubChem Substance ID:
329757996
NACRES:
NA.24

grade

analytical standard

Quality Level

200

assay

≥98.5% (HPLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable
solid phase extraction (SPE): suitable

mp

133-137 °C

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

CC(C)NCC(O)COc1cccc2[nH]c3ccccc3c12

InChI

1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3

InChI key

BQXQGZPYHWWCEB-UHFFFAOYSA-N

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General description

Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706030, T706025

Application

Carazolol may be used as a reference standard for the determination of the analyte:
  • In swine kidney by high-performance liquid chromatography with ultraviolet and fluorescence detection.
  • In animal tissues by high-performance liquid chromatography with electrochemical detection.

Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBD6162V
WXBD5523V
WXBD0370V
WXBC9263V
028M4031V

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Determination of tranquilisers and carazolol residues in animal tissue using high-performance liquid chromatography with electrochemical detection.
Rose MD and Shearer G
Journal of Chromatography A, 624(1-2), 471- 477 (1992)
Kimberly A Reynolds et al.
Journal of computer-aided molecular design, 23(5), 273-288 (2009-01-17)
The new beta(2) Adrenoceptor (beta(2)AR) crystal structures provide a high-resolution snapshot of receptor interactions with two particular partial inverse agonists, (-)-carazolol and timolol. However, both experimental and computational studies of GPCR structure are significantly complicated by the existence of multiple
Karin A Stephenson et al.
Journal of medicinal chemistry, 51(16), 5093-5100 (2008-07-29)
An efficient and general method has been developed for fluorine-18 labeling of beta-blockers that possess the propanolamine moiety. A new synthetically versatile intermediate, 3-(1-(benzyloxy)propan-2-yl)-2-oxooxazolidin-5-yl)methyl 4-methylbenzenesulfonate (13), was prepared and can be conjugated to any phenoxy core. To demonstrate the synthetic
Chris de Graaf et al.
Journal of medicinal chemistry, 51(16), 4978-4985 (2008-08-06)
The recently solved high-resolution X-ray structure of the beta2 adrenergic receptor has been challenged for its ability to discriminate inverse agonists/antagonists from partial/full agonists. Whereas the X-ray structure of the ground state receptor was unsuitable to distinguish true ligands with
Determination of residues of carazolol and a number of tranquilizers in swine kidney by high-performance liquid chromatography with ultraviolet and fluorescence detection.
Keukens HJ and Aerts MML
Journal of Chromatography A, 464, 149-161 (1991)
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