439215

Tetrahydrofuran

≥99.9%, suitable for HPLC, inhibitor-free

• Synonym(s): THF, Butylene oxide, Oxolane, Tetramethylene oxide
• Empirical Formula (Hill Notation): C₄H₈O
• CAS Number: 109-99-9
• Molecular Weight: 72.11
• Beilstein/REAXYS Number: 102391
• EC Number: 203-726-8
• MDL number: MFCD00005356
• UNSPSC Code: 12190000
• PubChem Substance ID: 329756429

Properties

• product name: Tetrahydrofuran, suitable for HPLC, ≥99.9%, inhibitor-free
• vapor density: 2.5 (vs air)
• Quality Level: 100
• vapor pressure: 114 mmHg ( 15 °C); 143 mmHg ( 20 °C)
• assay: ≥99.9%
• form: liquid
• autoignition temp.: 610 °F
• expl. lim.: 1.8-11.8 %
• technique(s): HPLC: suitable
• impurities: ≤0.015% peroxide (as H₂O₂); <0.02% water
• evapn. residue: <0.0005%
• refractive index: n20/D 1.407 (lit.)
• bp: 65-67 °C (lit.)
• mp: −108 °C (lit.)
• solubility: H₂O: soluble
• density: 0.889 g/mL at 25 °C (lit.)
• λ: H₂O reference
• UV absorption: λ: 212 nm A_max: 1.0; λ: 250 nm A_max: 0.180; λ: 300 nm A_max: 0.020; λ: 350-400 nm A_max: 0.005
• SMILES string: C1CCOC1
• InChI: 1S/C4H8O/c1-2-4-5-3-1/h1-4H2
• InChI key: WYURNTSHIVDZCO-UHFFFAOYSA-N

Description

General description

Tetrahydrofuran (THF) is a saturated cyclic ether with a potential use as a biofuel. Its combustion studies have been reported. Reports suggest it is a better promoter than 1,3 dioxolane for CO₂-hydrate formation. The effect of THF on the biological systems has been studied.

Application

Tetrahydrofuran may be used as a solvent in the following processes:

• Formation of diacetylinic polymers.
• RAFT polymerization of p-acetoxystyrene.
• Synthesis of di-tert-butyl-Phosphinoferrocene.

It may be used in the following processes:

• As mobile phase solvent in high-performance liquid chromatography.
• As a solvent in the preparation of spin-coated poly(bisphenol A decane ether).
• Formation of butyrolactone (BTL) by green oxidation method.
• As a solvent for lignin depolymerization to isolate phenolic monomer.

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Safety Information

• pictograms: GHS02,GHS08,GHS07
• signalword: Danger
• hcodes: H225,H302,H319,H335,H336,H351
• pcodes: P202 - P210 - P233 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• target_organs: Central nervous system, Respiratory system
• supp_hazards: EUH019
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: -6.2 °F - closed cup
• flash_point_c: -21.2 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter