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41694

Supelco

5-Hydroxydiclofenac

analytical standard

Synonym(s):

5-OH-DCF, 2-[(2,6-Dichlorophenyl)amino]-5-hydroxybenzeneacetic acid

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About This Item

Empirical Formula (Hill Notation):
C14H11Cl2NO3
CAS Number:
69002-84-2
Molecular Weight:
312.15
Beilstein/REAXYS Number:
4199419
MDL number:
MFCD01672033
UNSPSC Code:
41116107
PubChem Substance ID:
329756138
NACRES:
NA.24

grade

analytical standard

Quality Level

100

assay

≥97.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical

format

neat

storage temp.

−20°C

SMILES string

OC(CC1=CC(O)=CC=C1NC2=C(Cl)C=CC=C2Cl)=O

InChI

1S/C14H11Cl2NO3/c15-10-2-1-3-11(16)14(10)17-12-5-4-9(18)6-8(12)7-13(19)20/h1-6,17-18H,7H2,(H,19,20)

InChI key

VNQURRWYKFZKJZ-UHFFFAOYSA-N

General description

5-Hydroxydiclofenac, a monohydroxylated metabolite of diclofenac, belongs to the class of non-steroidal anti-inflammatory compounds.29}

Application

5-Hydroxydiclofenac may be used as an analytical standard for the determination of the analyte in biological samples and wastewater by liquid chromatography (LC) based techniques.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCC6673
BCBW2660
BCBR1013V
BCBR1013

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Jing Shi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 191, 1-7 (2017-10-02)
A novel flow injection chemiluminescence immunoassay for simple, sensitive and low-cost detection of diclofenac was established based on specific binding of antigen and antibody. Carboxylic resin beads used as solid phase carrier materials provided good biocompatibility and large surface-to-volume ratio
Simultaneous determination of diclofenac, its human metabolites and microbial nitration/nitrosation transformation products in wastewaters by liquid chromatography/quadrupole-linear ion trap mass spectrometry
Osorio V, et al.
Journal of Chromatography A, 1347(1), 63-71 (2014)
Klaudia Świacka et al.
Marine pollution bulletin, 141, 249-255 (2019-04-09)
Interest in the presence of pharmaceutically active compounds in the aquatic environment has been growing for over 20 years, yet very few studies deal with the metabolism of pharmaceuticals in marine organisms. In this study, the bioaccumulation under short-term conditions and
J M Monteagudo et al.
Journal of hazardous materials, 357, 457-465 (2018-06-24)
Degradation of a diclofenac aqueous solution was performed using persulfate anions activated by ultrasound. The objective of this study was to analyze different parameters affecting the diclofenac (DCF) removal reaction by the ultrasonic persulfate (US/PS) process and to evaluate the
C E Wilson et al.
Archives of toxicology, 92(6), 1953-1967 (2018-05-04)
The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached
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