383376

Potassium antimonyl tartrate trihydrate

ACS reagent, ≥99%

• Synonym(s): Antimony potassium tartrate trihydrate, Tartar emetic
• Empirical Formula (Hill Notation): C₈H₄K₂O₁₂Sb₂ · 3H₂O
• CAS Number: 28300-74-5
• Molecular Weight: 667.87
• EC Number: 234-293-3
• MDL number: MFCD00167056
• UNSPSC Code: 12352100
• PubChem Substance ID: 24863959
• NACRES: NA.21

Properties

• grade: ACS reagent
• Quality Level: 200
• assay: ≥99%; 99.0-103.0%
• form: powder
• impurities: ≤0.020 meq/g Titr. acid or base
• loss: ≤2.7% loss on drying
• mp: ≥300 °C (lit.)
• solubility: water: soluble
• cation traces: As: ≤0.015%
• SMILES string: O.O.O.[K+].[K+].O=C1O[Sb-]23OC1C4O[Sb-]5(OC(C(O2)C(=O)O3)C(=O)O5)OC4=O
• InChI: 1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4
• InChI key: WBTCZEPSIIFINA-UHFFFAOYSA-J

Description

General description

Potassium antimonyl tartrate trihydrate is a metalloid salt in which the antimony is in trivalent state (SbIII). Potassium antimonyl tartrate (PAT) is an antiparasitic agent predominantly used for treating infections caused by the parasite Leishmania. Its antiangiogenic and antitumor properties has been investigated in nonsmall-cell lung cancer (NSCLC) cells. Studies in Chinese hamster ovary cells show that it may prevent the repair of DNA double strand breaks (DSBs) caused by γ-irradiation.

Application

Potassium antimonyl tartrate trihydrate has been used in the dose-inhibition experiments to evaluate the dose-inhibition curves of antimony-based antileishmanial compounds against Leishmania promastigotes in medium 199.

Potassium antimonyl tartrate trihydrate may be used to prepare antimony (Sb(III)) stock solution in deionized water (100mg/L). It may also be employed in the spectrophotometric determination of total phosphorus in dry sediments.

Safety Information

• pictograms: GHS06,GHS09
• signalword: Danger
• hcodes: H301,H315,H317,H332,H411
• pcodes: P261 - P273 - P280 - P301 + P310 - P302 + P352 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1
• Storage Class: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves