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34124

Supelco

Deoxynivalenol solution

100 μg/mL in acetonitrile, analytical standard

Synonym(s):

3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one, DON, Vomitoxin

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About This Item

Empirical Formula (Hill Notation):
C15H20O6
CAS Number:
Molecular Weight:
296.32
EC Number:
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

shelf life

limited shelf life, expiry date on the label

concentration

100 μg/mL in acetonitrile

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

single component solution

storage temp.

−20°C

SMILES string

CC1=C[C@H]2O[C@@H]3[C@H](O)C[C@@](C)([C@]34CO4)[C@@]2(CO)[C@H](O)C1=O

InChI

1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1

InChI key

LINOMUASTDIRTM-QGRHZQQGSA-N

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General description

Deoxynivalenol belongs to the group of tetracyclic sesquiterpenoid mycotoxins called trichothecenes, produced by Fusarium fungi, naturally occurring in small grains and infected corn.

Check out our entire range of trichothecene type mycotoxin reference materials
Deoxynivalenol is frequently found in cereals and agricultural products including, corn, barley, oats, rye, maize, wheat, malt, bread, beer, etc. It is a mycotoxin and primarily affects the livestock industry by reducing the food intake in farm animals. The effect of DON contamination in cereals and other food samples serves as one of the factors of Kashin-Beck disease, a chronic and endemic osteoarticular disorder.

Application

Deoxynivalenol solution has been used as an analytical reference standard for the quantification of the analyte in cornmeal and wheat meal matrices using high-performance liquid chromatography with UV detection (HPLC-UV). It is used as an analytical standard in investigating its toxicity mechanism on human chondrocytes by microarray and bioinformatics analysis.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Certificates of Analysis (COA)

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Determination of 12 type A and B trichothecenes in cereals by liquid chromatography? electrospray ionization tandem mass spectrometry
Klotzel M, et al.
Journal of Agricultural and Food Chemistry, 53, 8904-8910 (2005)
Production of monoclonal antibodies for the specific detection of deoxynivalenol and 15-acetyldeoxynivalenol by ELISA
Sinha.CR, et al.
Journal of Agricultural and Food Chemistry, 43, 1740-1744 (1995)
Lei Yang et al.
Toxicology letters, 321, 61-68 (2019-12-22)
T-2 toxin and deoxynivalenol (DON) are two representative mycotoxins that are commonly found in cereals and agricultural products. As T-2 toxin and DON are considered the cause of Kashin-Beck disease, a special osteoarticular disease, chondrocytes would be a vital target
Dirk Rohweder et al.
Archives of animal nutrition, 67(1), 37-47 (2013-01-23)
Fusarium infections do not only affect the grain, but also the rest of the plant, which result in contamination of plants with the mycotoxin deoxynivalenol (DON). The bioavailability of DON may be influenced by the matrix due to the differences
Michihiro Ito et al.
Applied and environmental microbiology, 79(5), 1619-1628 (2013-01-01)
Deoxynivalenol (DON) is a natural toxin of fungi that cause Fusarium head blight disease of wheat and other small-grain cereals. DON accumulates in infected grains and promotes the spread of the infection on wheat, posing serious problems to grain production.

Articles

Supel Tox DON SPE cartridges required fewer process steps and fewer reagents than the IAC cleanup method for wheat matrix samples prior to HPLC analysis.

Supel Tox DON SPE cartridges required fewer process steps and fewer reagents than the IAC cleanup method for wheat matrix samples prior to HPLC analysis.

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Mycotoxin chemistry is diverse with some toxins being relatively harmless and some very dangerous like aflatoxins, citrinin, ergot alkaloids fumonisins. For all Food & Beverage manufacturers and testers, find a detailed list of products for each step of your mycotoxin analysis workflow.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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