296309

1,4-Dioxane

anhydrous, 99.8%

• Synonym(s): Diethylene oxide, Dioxane
• Empirical Formula (Hill Notation): C₄H₈O₂
• CAS Number: 123-91-1
• Molecular Weight: 88.11
• Beilstein: 102551
• EC Number: 204-661-8
• MDL number: MFCD00006571
• PubChem Substance ID: 57648388
• NACRES: NA.21

Properties

• grade: anhydrous
• Quality Level: 200
• vapor density: 3 (vs air)
• vapor pressure: 27 mmHg ( 20 °C); 40 mmHg ( 25 °C)
• assay: 99.8%
• form: liquid
• autoignition temp.: 356 °F
• expl. lim.: 22 %
• impurities: <0.003% water; <0.005% water (100 mL pkg)
• evapn. residue: <0.0003%
• refractive index: n20/D 1.422 (lit.)
• pH: 6.0-8 (20 °C, 500 g/L)
• bp: 100-102 °C (lit.)
• mp: 10-12 °C (lit.)
• density: 1.034 g/mL at 25 °C (lit.)
• SMILES string: C1COCCO1
• InChI: 1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2
• InChI key: RYHBNJHYFVUHQT-UHFFFAOYSA-N

Description

Application

1,4-Dioxane may undergo nickel-catalyzed oxidative arylation with arylboronic acids to form α-arylated ethers.
It may be used as a solvent to synthesize:

• (Chloromethyl)dimethylphenylsilane from chloro(chloromethyl)dimethylsilane via zinc-catalyzed substitution reaction with phenylmagnesium bromide.
• N-(2,2,2-trifluoro-1-hydroxyethyl)-acetamide from 2,2,2-trifluoro-1-methoxyethanol and acetamide.

Packaging

100, 12×100 mL in Sure/Seal™

1, 6×1, 2 L in Sure/Seal™

18, 200 L in Pure-Pac™ 1

View returnable container options.

Other Notes

The article number 296309-4X2L will be discontinued. Please order the single bottle 296309-2L which is physically identical with the same exact specifications.

Safety Information

• Pictograms: GHS02,GHS07,GHS08
• Signal Word: Danger
• Hazard Statements: H225 - H319 - H335 - H350
• Precautionary Statements: P202 - P210 - P233 - P240 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Target Organs: Respiratory system
• Supplementary Hazards: EUH019 - EUH066
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 51.8 °F - closed cup
• Flash Point(C): 11 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves