MilliporeSigma
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105945

Sigma-Aldrich

Phenolphthalein

ACS reagent

Synonym(s):
3,3-Bis(4-hydroxyphenyl)-1(3H)-isobenzofuranone
Empirical Formula (Hill Notation):
C20H14O4
CAS Number:
Molecular Weight:
318.32
Colour Index Number:
764
Beilstein:
284423
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.47

grade

ACS reagent

Quality Level

form

powder

technique(s)

titration: suitable

visual transition interval

8.0-10, colorless to red

mp

261-263 °C (lit.)

solubility

acetone: soluble

density

1.27 g/cm3 at 32 °C

λmax

374 nm (2nd)
552 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

Oc1ccc(cc1)C2(OC(=O)c3ccccc23)c4ccc(O)cc4

InChI

1S/C20H14O4/c21-15-9-5-13(6-10-15)20(14-7-11-16(22)12-8-14)18-4-2-1-3-17(18)19(23)24-20/h1-12,21-22H

InChI key

KJFMBFZCATUALV-UHFFFAOYSA-N

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General description

Phenolphthalein is present as a nonionic, lipophilic lactone in aqueous neutral solutions. It exists as a hydrophilic dianion in alkaline solutions.

Application

Phenolphthalein is widely used as a pH indicator in biology and medicine. Its other applications include
  • in the assay to estimate total acidity in vinegar
  • in the assessment of penetration of sodium hydroxide into potatoes following chemical peeling
  • as a model organic compound in the evaluation of the capture efficiency of various cyclodextrin constructs such as nanofiber-CD

Packaging

100, 500 g in poly bottle
2.5 kg in poly drum

Biochem/physiol Actions

Phenolphthalein is colorless in acidic solutions and turns pink in basic solutions.

Pictograms

Exclamation markHealth hazard

Signal Word

Danger

Hazard Classifications

Carc. 1B - Muta. 2 - Repr. 2 - Skin Irrit. 2

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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