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Anti-pan-Shank Antibody, clone N23B/49

clone N23B/49, from mouse

SH3 and multiple ankyrin repeat domains 2, SH3 and multiple ankyrin repeat domains protein 2, proline-rich synapse associated protein 1, cortactin SH3 domain-binding protein, Cortactin-binding protein 1, Proline-rich synapse-associated protein 1, cortact

Quality Level

biological source


antibody form

purified antibody

antibody product type

primary antibodies


N23B/49, monoclonal

species reactivity

rat, mouse, human


immunohistochemistry: suitable (paraffin)
western blot: suitable



NCBI accession no.

UniProt accession no.

shipped in

wet ice

Gene Information

human ... SHANK2(22941)

General description

Shank1, Shank2, and Shank3 make up a family of proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank contains multiple domains for protein-protein interaction including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile α motif domain, and a proline-rich region. Alternative splicing in the Shank family may be a mechanism that regulates the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain.


Recombinant protein consisting of SH3/PDZ domain of rat Shank2.


Research Sub Category
Synapse & Synaptic Biology
Detect pan-Shank using this Anti-pan-Shank Antibody, clone N23B/49 validated for use in WB, IH(P).
Research Category
Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected Shank in rat cerebellum tissue.

Western Blot Analysis: A previous lot of this antibody detected Shank in extracts of COS-1 cells transiently transfected with Shank1, Shank2 or Shank3 plasmids. Courtesy of James Trimmer, UC Davis/NIH NeuroMab Facility.


Evaluated by Western Blot in rat brain membrane tissue lysate.

Western Blot Analysis: 2 µg/mL of this antibody detected Shank on 10 µg of rat brain membrane tissue lysate.

Target description

~160 kDa observed. Other isoforms may be observed in some lysates.

Physical form

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Rat brain membrane tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Quality

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