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Key Documents

MAB4122

Sigma-Aldrich

Anti-Multi-Drug Resistance Related Protein Antibody, clone MRPm6

culture supernatant, clone MRPm6, Chemicon®

Synonym(s):

MRP

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

300

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRPm6, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

flow cytometry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_004996.3
NM_019862.2
NM_019898.2
NM_019899.2
NM_019900.2
NM_019901.1
NM_019902.1

UniProt accession no.

P33527

shipped in

wet ice

Gene Information

human ... ABCC1(4363)

Related Categories

Specificity

MRPm6 reacts with an internal epitope of MRP, a 180-195 kDa transmembrane transporter protein overexpressed in various human non-P-glycoprotein MDR tumor cell lines. MRPm6 was raised against a bacterial fusion protein of MRP, containing a segment of 170 amino acids in the carboxy terminal end and part of the carboxy proximal nucleotide binding domain of the protein. MRPm6 does not cross-react with the human MDR1 and MDR3 gene products (Flens et al., 1994).

Application

Anti-Multi-Drug Resistance Related Protein Antibody, clone MRPm6 is an antibody against Multi-Drug Resistance Related Protein for use in FC, WB, IH(P).
Western blot

Flow Cytometry

Immunohistochemistry on frozen and paraffin embedded tissue

sections: 1:20.

Note: For cellular detection permeabilization is required.

Optimal working dilutions must be determined by end user.

Physical form

Tissue Culture Supernatant. Liquid containing 0.1% sodium azide and 0.7% BSA.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M L Den Boer et al.
Leukemia, 11(7), 1078-1085 (1997-07-01)
The clinical relevance of multidrug resistance (MDR)-related proteins in childhood acute lymphoblastic leukemia (ALL) is largely unknown. The diversity of techniques, fixation methods, storage of cells (fresh or cryopreserved) etc, may contribute to discrepancies observed between several studies. We therefore
Tissue distribution of the multidrug resistance protein.
Flens, M J, et al.
The American Journal of Pathology, 148, 1237-1247 (1996)
D Schadendorf et al.
The American journal of pathology, 147(6), 1545-1552 (1995-12-01)
Melanoma cells often display a multidrug-resistant phenotype, but the mechanisms involved are largely unknown. We have studied here the recently identified transport-associated proteins, MRP and LRP, and the well-known drug resistance marker P-glycoprotein using a panel of 16 human melanoma

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