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Key Documents

ABE295

Sigma-Aldrich

Anti-Zinc Finger Protein 260 Antibody

serum, from rabbit

Synonym(s):

Zinc finger protein 260, Zfp-260, Pancreas-only zinc finger protein 1, POZF-1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, mouse, human

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_059060

UniProt accession no.

Q62981

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ZNF260(339324)

General description

Zinc finger protein 260 (PEX1) is transcription factor, which belongs to the krueppel C2H2-type zinc-finger protein family. It is expressed in fetal and adult heart, lung, skeletal muscle, and adrenal glands. It responds to changes in the activity of alpha1-adrenergic receptors; and binds to PE response elements in genes involved in cardiac function, such as ANF/NPPA.

Immunogen

MBP-tagged recombinant protein corresponding to rat Zinc Finger Protein 260.

Application

Detect Zinc Finger Protein 260 using this Anti-Zinc Finger Protein 260 Antibody validated for use in Western Blotting, ICC & IHC.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected Zinc Finger Protein 260 in 10 µg of mouse heart tissue lysate.

Immunocytocchemistry Analysis: A representative lot from an independent laboratory detected Zinc Finger Protein 260 in adeno-HA-AS-PEX1-infected rat primary cardiomyocytes (Komati, H., et al. (2011). J Biol Chem. 286(2):1508-1516.).

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Zinc Finger Protein 260 in alpha-MHCMerCreMer/CAT-PEX1 transgenic mouse heart tissue treated with Tamoxifen (Komati, H., et al. (2011). J Biol Chem. 286(2):1508-1516.).

Quality

Evaluated by Western Blot in human heart tissue lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected Zinc Finger Protein 260 in 10 µg of human heart tissue lysate.

Target description

~46 kDa observed. An uncharacterized band may be observed at ~16 kDa in some cell lysates.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hiba Komati et al.
The Journal of biological chemistry, 286(2), 1508-1516 (2010-11-06)
Pressure and volume overload induce hypertrophic growth of postnatal cardiomyocytes and genetic reprogramming characterized by reactivation of a subset of fetal genes. Despite intense efforts, the nuclear effectors of cardiomyocyte hypertrophy remain incompletely defined. Endothelin-1 (ET-1) plays an important role

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