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Key Documents

AB5988P

Sigma-Aldrich

Anti-Amyloid Precursor Protein Antibody, Domain 770

Chemicon®, from rabbit

Synonym(s):

APP

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, monkey

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NM_000484.2
NM_201413.1
NM_201414.1

UniProt accession no.

P05067

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... APP(351)

Specificity

Amyloid precursor protein (APP), domain 770, but not APP751 or APP695.

Immunogen

Epitope: OX2 Domain 770
Synthetic peptide corresponding to the OX2 domain of APP770.

Application

Anti-Amyloid Precursor Protein Antibody, Domain 770 detects level of Amyloid Precursor Protein & has been published & validated for use in IP, WB, IC, IH.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Western Blot

Immunohistochemistry on cold methanol fixed tissues.

Immunocytochemistry

Immunoprecipitation

Optimal working dilutions must be determined by the end user.

Physical form

Affinity purified immunoglobulin. Liquid in TRIS-buffered saline with 0.01% sodium azide.

Storage and Stability

Maintain at 2-8°C in undiluted aliquots for up to 6 months.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Hitomi Komura et al.
iScience, 13, 452-477 (2019-03-05)
We identified ∼30-mer amyloid-β protein (Aβ) assemblies, termed amylospheroids, from brains of patients with Alzheimer disease (AD) as toxic entities responsible for neurodegeneration and showed that Na+,K+-ATPase α3 (NAKα3) is the sole target of amylospheroid-mediated neurodegeneration. However, it remains unclear

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