AB5480
Anti-Superoxide Dismutase 1 Antibody, aa 25-37
serum, Chemicon®
Synonym(s):
SOD1
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
should not react with
mouse
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... SOD1(6647)
General description
Mutations in the copper/ zinc superoxide dismutase (SOD1) gene are associated with 15- 20% of the familial forms of motoneuron disease. This 153 amino acid metalloenzyme is expressed in virtually all cells of all organisms above bacteria and is highly conserved across species, although some minor variations do occur. The incorporation of the mutated form of the SOD1 human gene into a transgenic mouse leads to the onset of the disease that closely resembles the human condition. These animals become weak at about 2-4 months of age and rapidly lose function, which results in death 4- 6 weeks later.
Specificity
Superoxide Dismutase 1 (SOD1), human specific.
Immunogen
Epitope: aa 25-37
Synthetic peptide corresponding to amino acids 25-37 of human SOD1.
Application
Anti-Superoxide Dismutase 1 Antibody, aa 25-37 detects level of Superoxide Dismutase 1 & has been published & validated for use in WB.
Western blotting: 1:500
Optimal working dilutions must be determined by end user.
Optimal working dilutions must be determined by end user.
Storage and Stability
Maintain lyophilized material at -70°C (dry) for up to 12 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Adherent monomer-misfolded SOD1.
Watanabe, Y; Morita, E; Fukada, Y; Doi, K; Yasui, K; Kitayama, M; Nakano, T; Nakashima, K
Testing null
Nerve terminal degeneration is independent of muscle fiber genotype in SOD1 mice.
Carrasco, DI; Bichler, EK; Seburn, KL; Pinter, MJ
Testing null
S E Bartlett et al.
Journal of neuroscience methods, 98(1), 63-67 (2000-06-06)
Mutations in the copper/zinc superoxide dismutase (SOD1) gene are associated with 15-20% of the familial forms of motor neuron disease. Mice where a transgene has been incorporated that encodes for the human SOD1 mutation develop a form of motor neurone
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