AB3040
Anti-Uncoupling Protein 2 Antibody
Chemicon®, from rabbit
Synonym(s):
UCP2
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
mouse ... Ucp2(22228)
Specificity
Uncoupling Protein 2 (UCP2), mouse. Mouse UCP2 is a 309 amino acid mitochondrial uncoupling protein (Fleury et al. 1997). It is only 59% homologous with UCP1 found in brown adipose tissues. Mouse UCP2 (chromosome 7) has approximately 95% homology with human UCP2 located on chromosome 11 (Fleury et al. 1997). UCP2 has wide tissue distribution in mouse tissues (brain, kidney, liver, brown adipose tissue, heart, and muscle). UCP2 may play a critical role in energy balance, body weight, and thermoregulation (Fleury et al. 1997; Flier & Lowell 1997).
SPECIES REACTIVITIES: The antibody has not yet been tested for cross-reactivity to other species. The sequence used for immunization shows 100% homology in rat, 86% homology in human, porcine, canine and bovine.
SPECIES REACTIVITIES: The antibody has not yet been tested for cross-reactivity to other species. The sequence used for immunization shows 100% homology in rat, 86% homology in human, porcine, canine and bovine.
Immunogen
14 aa peptide sequence near the C-terminus of the mouse UCP2 (Fleury et al. 1997). The peptide has no significant homology with UCP1 or UCP3 (Boss et al. 1997). This peptide is available for blocking as catalog number AG788.
Application
Anti-Uncoupling Protein 2 Antibody is an antibody against Uncoupling Protein 2 for use in ELISA & WB.
Research Category
Metabolism
Metabolism
Research Sub Category
Ion & Transport Channels
Ion & Transport Channels
Western Blotting: 1-10 μg/mL using Chemiluminescence technique.
ELISA: 1:10,000-1:100,000; using 50-100 ng UCP2 control peptide/well.
Optimal working dilutions must be determined by end user.
ELISA: 1:10,000-1:100,000; using 50-100 ng UCP2 control peptide/well.
Optimal working dilutions must be determined by end user.
Physical form
Affinity purified immunoglobulin. Liquid in PBS, pH 7.4 with 0.1% BSA as stabilizer and 0.02% sodium merthiolate.
Storage and Stability
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Obesity research springs a proton leak.
J S Flier et al.
Nature genetics, 15(3), 223-224 (1997-03-01)
C Fleury et al.
Nature genetics, 15(3), 269-272 (1997-03-01)
A mitochondrial protein called uncoupling protein (UCP1) plays an important role in generating heat and burning calories by creating a pathway that allows dissipation of the proton electrochemical gradient across the inner mitochondrial membrane in brown adipose tissue, without coupling
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