Anti-LYVE1 Antibody

from rabbit, purified by affinity chromatography

Cell surface retention sequence-binding protein 1, Extracellular link domain-containing protein 1, Hyaluronic acid receptor, cell surface retention sequence binding protein-1, extracellular link domain containing 1, extracellular link domain-containing 1

biological source


Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies



purified by

affinity chromatography

species reactivity


species reactivity (predicted by homology)

mouse (based on 100% sequence homology)


immunohistochemistry: suitable



NCBI accession no.

UniProt accession no.

shipped in

wet ice

Gene Information

human ... LYVE1(10894)

General description

LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE1 may function in lymphatic hyaluronan transport. Additionally, LYVE1 has a role in tumor metastasis.


Rat (90% sequence homology).
This antibody recognizes LYVE1.


Epitope: Unknown
KLH-conjugated linear peptide corresponding to mouse LYVE1.


Research Sub Category
Tumor Markers
Not recommended to work in western blot using mouse liver lysate.
Anti-LYVE1 Antibody is an antibody against LYVE1 for use in IH.
Research Category
Apoptosis & Cancer


Evaluated by Immunohistochemistry in ovarian cancer tissue.

Immunohistochemistry Analysis: 1:1,000 dilution of this antibody detected LYVE1 in ovarian cancer tissue.

Target description

~ 40 kDa


Replaces: 07-538

Physical form

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Affinity purified

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Ovarian cancer tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


12 - Non Combustible Liquids

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Abdi Ghaffari et al.
Breast cancer research : BCR, 16(5), 438-438 (2014-09-19)
Recent evidence suggests that tumour lymphangiogenesis promotes lymph node metastasis, a major prognostic factor for survival of breast cancer patients. However, signaling mechanisms involved in tumour-induced lymphangiogenesis remain poorly understood. The expression of ezrin, a membrane cytoskeletal crosslinker and Src...

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