AB2984
Anti-Integrin beta-3 Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), Platelet membrane glycoprotein IIIa, integrin beta-3, platelet glycoprotein IIIa, CD61 antigen
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, pig
species reactivity (predicted by homology)
rat (based on 100% sequence homology), canine (based on 100% sequence homology), porcine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), bovine (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ITGB3(3690)
General description
Integrin beta-3 is a member of the Integrin receptor family. The integrin family has been shown to be instrumental in cell adhesion to extracellular matrix proteins and can be found in certain cell to cell adhesions. Integrins are also important in transmembrane connections and intracellular signaling. Integrins are key to understanding many human diseases as they are commonly the receptors. Integrins have been linked to many different parts of cellular operations including; development, immunity, leukocyte traffic, homeostasis and even cancer. Once integrin beta-3 is activated, it binds fibrinogen which causes platelet to platelet interaction effectively cutting off a ruptured endothelial surface.
Specificity
Other homologies: Mouse (93% sequence homology.)
This antibody recognizes the extracellular domain of integrin beta-3.
Immunogen
Epitope: Extracellular Domain
KLH-conjugated linear peptide corresponding to human integrin beta-3 at the extracellular domain.
Application
Anti-Integrin beta-3 Antibody is an antibody against Integrin beta-3 for use in WB, IP, IH(P).
Immunohistochemistry Analysis: A 1:500 dilution from a previous lot detected intergin beta-3 in skin membrane tissue.
Immunoprecipitaiton Analysis: 10 µg from a previous lot immunoprecipitated integrin beta-3 from U251 RIPA lysate.
Immunoprecipitaiton Analysis: 10 µg from a previous lot immunoprecipitated integrin beta-3 from U251 RIPA lysate.
Research Category
Cell Structure
Cell Structure
Research Sub Category
ECM Proteins
ECM Proteins
Quality
Evaluated by Western Blot in U251 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected integrin beta-3 in 10 µg of U251 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected integrin beta-3 in 10 µg of U251 cell lysate.
Target description
~85 kDa observed.
Uncharacterized bands may be observed in some lysates.
Uncharacterized bands may be observed in some lysates.
Linkage
Replaces: 04-1060
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
U251 cell lysate
U251 cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
Pricing
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Naohiro Miyashita et al.
Annals of hematology, 97(4), 629-640 (2018-01-31)
We identified a novel heterozygous ITGB3 p.T720del mutation in a pedigree with macrothrombocytopenia exhibiting aggregation dysfunction. Platelet aggregation induced by ADP and collagen was significantly reduced, while ristocetin aggregation was normal. Integrin αIIbβ3 was partially activated in a resting status
Ayuko Hoshino et al.
Nature, 527(7578), 329-335 (2015-11-03)
Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely
Ravi Chakra Turaga et al.
Nature communications, 7, 11675-11675 (2016-06-01)
Integrin αvβ3 expression is altered in various diseases and has been proposed as a drug target. Here we use a rational design approach to develop a therapeutic protein, which we call ProAgio, that binds to integrin αvβ3 outside the classical
Sandrine Evellin et al.
Molecular and cellular biology, 33(6), 1198-1209 (2013-01-16)
To form three-dimensional capillary tubes, endothelial cells must establish contacts with the extracellular matrix that provides signals for their proliferation, migration, and differentiation. The transcription factor Fosl1 plays a key role in the vasculogenic and angiogenic processes as Fosl1 knockout
Elena Vecino et al.
PloS one, 10(5), e0125250-e0125250 (2015-05-29)
Retinal ganglion cells (RGCs) are exposed to injury in a variety of optic nerve diseases including glaucoma. However, not all cells respond in the same way to damage and the capacity of individual RGCs to survive or regenerate is variable.
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