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Key Documents

8.08388

Sigma-Aldrich

1,2,4-Triazole

for synthesis

Synonym(s):

1,2,4-Triazole

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About This Item

Empirical Formula (Hill Notation):
C2H3N3
CAS Number:
288-88-0
Molecular Weight:
69.07
MDL number:
MFCD00005228
UNSPSC Code:
12352005
EC Index Number:
206-022-9
NACRES:
NA.22

Quality Level

200

assay

≥98.0% (GC)

form

solid

potency

1650 mg/kg LD50, oral (Rat)
3129-4200 mg/kg LD50, skin (Rabbit)

pH

8 (20 °C, 10 g/L in H2O)

bp

259-261 °C/1013 hPa

mp

119-122 °C

density

1.15 g/cm3 at 130 °C

bulk density

550 kg/m3

storage temp.

2-30°C

InChI

1S/C2H3N3/c1-3-2-5-4-1/h1-2H,(H,3,4,5)

InChI key

NSPMIYGKQJPBQR-UHFFFAOYSA-N

Application

  • Chemistry of 1, 2, 4-triazole: a review article: This comprehensive review explores the broad applications of 1,2,4-triazole in pharmaceuticals, demonstrating its role in enhancing antibacterial, antifungal, and antioxidant properties (Shneine et al., 2016).
  • Combination of 1, 2, 3-triazole and 1, 2, 4-triazole frameworks for new high-energy and low-sensitivity compounds: Discusses the synthesis of energetic materials combining 1,2,4-triazole with other high-energy frameworks, aiming to enhance performance and safety (Yao et al., 2021).
  • 1, 3, 4-Oxadiazole, 1, 3, 4-thiadiazole and 1, 2, 4-triazole derivatives as potential antibacterial agents: Examines derivatives of 1,2,4-triazole for potential use in antibacterial treatments, reflecting on their pharmacological importance (Othman et al., 2019).
  • Recent developments on 1, 2, 4-triazole nucleus in anticancer compounds: a review: Reviews the incorporation of the 1,2,4-triazole nucleus in various anticancer compounds, showcasing the therapeutic potential of this moiety (Kaur et al., 2016).

Analysis Note

Assay (GC, area%): ≥ 98.0 % (a/a)
Melting range (lower value): ≥ 117 °C
Melting range (upper value): ≤ 121 °C
Identity (IR): passes test

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 2

flash_point_f

338.0 °F

flash_point_c

170 °C

Certificates of Analysis (COA)

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