605195
Thrombin, Human Plasma, High Activity
Synonym(s):
Thrombin, Human Plasma, High Activity
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About This Item
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biological source
human plasma
Quality Level
form
lyophilized solid
specific activity
≥2800 NIH units/mg protein
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
water: 1 mg/mL, cloudy
shipped in
wet ice
storage temp.
−20°C
General description
Designed for use in thrombin clotting time tests. Key enzyme that activates factor XIII and converts fibrinogen into fibrin.
Designed for use in thrombin clotting time tests. Serine protease formed in the plasma during the clotting process from prothrombin, calcium, and thromboplasmin. Acts on the soluble plasma protein fibrinogen to convert it to an insoluble fibrin clot. Prepared from homogenous human prothrombin by activation with Factor Xa, Factor Va, and phospholipid. Designed for use in thrombin time tests.
Warning
Toxicity: Harmful (C)
Unit Definition
One unit is determined by comparison with a standard curve prepared using the Bureau of Biologics standard thrombin.
Physical form
Lyophilized from 200 mM NaCl, 50 mM sodium citrate, 0.1% PEG-8000, pH 6.5.
Preparation Note
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Analysis Note
Complete activation from homogeneous prothrombin by SDS-PAGE
Other Notes
Forsberg, G., et al. 1992. J. Protein Chem.11, 201.
Garcia, J.G. 1992. J. Lab. Clin. Med.120, 513.
Scarborough, R.M., et al. 1992. J. Biol. Chem.267, 13146.
Weigel, L.M., et al. 1992. Infect. Immun.60, 1568.
Garcia, J.G. 1992. J. Lab. Clin. Med.120, 513.
Scarborough, R.M., et al. 1992. J. Biol. Chem.267, 13146.
Weigel, L.M., et al. 1992. Infect. Immun.60, 1568.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
Certificates of Analysis (COA)
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