580553

(±)-Taxifolin hydrate

An antioxidant flavonoid that scavenges superoxide (1.5 x 10⁵ M⁻¹ s⁻¹) and suppresses the cytotoxicity of superoxide and hydrogen peroxide in Chinese hamster V79 cells.

• Synonym(s): 3,3′,4′,5,7-Pentahydroxydihydroflavone Hydrate, Dihydroquercetin Hydrate, 3,3′,4′,5,7-Pentahydroxyflavanone hydrate, Dihydroquercetin hydrate
• Empirical Formula (Hill Notation): C₁₅H₁₂O₇ · xH₂O
• CAS Number: 24198-97-8
• Molecular Weight: 304.25 (anhydrous basis)
• MDL number: MFCD11044454
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white to off-white
• solubility: ethanol: 20 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: O.O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c3ccc(O)c(O)c3
• InChI: 1S/C15H12O7.H2O/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6;/h1-5,14-19,21H;1H2/t14-,15+;/m0./s1
• InChI key: DNQPGSVMBPSRIR-LDXVYITESA-N

Description

General description

An antioxidant flavonoid that scavenges superoxide (1.5 x 10⁵ M^-1 s^-1) and suppresses the cytotoxicity of superoxide and hydrogen peroxide in Chinese hamster V79 cells.

An antioxidant flavonoid that suppresses the cytotoxicity of superoxide ions and hydrogen peroxide in Chinese hamster V79 cells.

Biochem/physiol Actions

Cell permeable: no

Flavonoid, antioxidant. Inhibits lipogenesis in cancer cells, most likely by targeting fatty acid synthase activity.

Primary Target
An antioxidant flavonoid that scavenges superoxide

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Other Notes

Kostyuk, V.A., et al. 1998. Arch. Biochem. Biophys. 355, 43.
Bors, W., et al. 1995. Free Radic. Biol. Med. 19, 45.
Nakayama, T., et al. 1994. Cancer Res. 54, 1991s.
Nakayama, T., et al. 1993. Biochem. Pharmacol. 45, 265.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable