5.05823

Galectin-1 Antagonist, DB21

• Synonym(s): Galectin-1 Antagonist, DB21, SVQNvaKL-[DBF]-IIVKLNA
• Empirical Formula (Hill Notation): C₈₃H₁₃₂N₁₈O₁₇
• Molecular Weight: 1654.05
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: powder
• potency: 3 μM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 10 mg/mL
• storage temp.: −20°C

Description

General description

A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC₅₀ = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.

A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC₅₀ = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.

Biochem/physiol Actions

Primary Target
Galectin-1

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

SVQMKNva-[DBF]-IIVKLNA

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Dings, R.P., et al, 2013, J. Pharm. Exp. Ther.344, 589.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable