374000

Helenalin, A. chamissonis ssp. foliosa

• Synonym(s): Helenalin, A. chamissonis ssp. foliosa
• Empirical Formula (Hill Notation): C₁₅H₁₈O₄
• CAS Number: 6754-13-8
• Molecular Weight: 262.30
• UNSPSC Code: 51111800
• NACRES: NA.77

Properties

• assay: ≥95% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated; protect from light
• color: white to off-white
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C15H18O4/c1-7-6-10-12(8(2)14(18)19-10)13(17)15(3)9(7)4-5-11(15)16/h4-5,7,9-10,12-13,17H,2,6H2,1,3H3/t7-,9+,10-,12-,13+,15+/m1/s1
• InChI key: ZVLOPMNVFLSSAA-XEPQRQSNSA-N

Description

General description

A cell-permeable anti-inflammatory sesquiterpene lactone that acts as a specific NF-κB-DNA binding inhibitor by irreversibly alkylating free sulfhydryls of the cysteine residues on the p65 subunit. Exhibits no effect against the DNA-binding activity of the homodimer of p50 subunit, nor does it affect cellular NF-κB activation/nuclear translocation or IκB dissociation/degradation. An excellent research tool for studying NF-κB-mediated biological processes both in cultures in vitro and in animals in vivo.

Packaging

Packaged under inert gas

Warning

Toxicity: Toxic (F)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Boulanger, D., et al. 2007. Vet. Microbiol.119, 330.
Auld, C.A., et al. 2006. Biochem. Biophys. Res. Commun.346, 314.
Huang, P.R., et al. 2005. Cancer Lett.227, 169.
Lyss, G., et al. 1998. J. Biol. Chem.273, 33508.
Lyss, G., et al. 1997. Biol. Chem.378, 951.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable