219385

Cathepsin B Inhibitor II

The Cathepsin B Inhibitor II controls the biological activity of Cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonym(s): Cathepsin B Inhibitor II, Ac-LVK-CHO
• Empirical Formula (Hill Notation): C₁₉H₃₆N₄O₄
• Molecular Weight: 384.51
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: water: 1 mg/mL
• shipped in: ambient
• storage temp.: −70°C

Description

General description

A more active lysinal analog of Leupeptin (Cat. No. 108975). A more potent inhibitor of cathepsin B (IC₅₀ = 4 nM) compared to leupeptin (IC₅₀ = 310 nM).

Lysinal analog of Leupeptin (Cat. No. 108975). A more potent inhibitor of cathepsin B (IC₅₀ = 4 nM) than of leupeptin (IC₅₀ = 310 nM). Note: this peptide forms cyclic isomers.

Note: this peptide forms cyclic isomers.

Biochem/physiol Actions

Cell permeable: no

Primary Target
cathepsin B

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 4 nM against cathepsin B

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Leu-Val-lysinal

Reconstitution

Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.

Other Notes

McConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable