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description
Bafilomycin A1 is a specific potent inhibitor of vacuolar-type H+-ATPases, and blocks lysosomal cholesterol transport in macrophages.
Quality Level
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
storage temp.
−20°C
Application
Bafilomycin A1 has been used:
- as an autophagy inhibitor to study its effect on traumatic brain injury (TBI)-induced cell death and lesions in mice
- to treat neurons for pH luorin assays to measure endocytosis during synaptic activity
- to block autophagy in mouse embryonic fibroblasts
Biochem/physiol Actions
Inhibitor Type: Kinase
Physical form
C35H58O9
Storage and Stability
3 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
Certificates of Analysis (COA)
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