118415

ADP-HPD, Dihydrate, Ammonium Salt

≥95% (HPLC), lyophilized solid, PARG inhibitor, Calbiochem^®

• Synonym(s): ADP-HPD, Dihydrate, Ammonium Salt, Adenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄
• Empirical Formula (Hill Notation): C₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
• Molecular Weight: 595.39
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• product name: ADP-HPD, Dihydrate, Ammonium Salt, ADP-HPD, Dihydrate is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC₅₀ = 120 nM).
• Quality Level: 100
• assay: ≥95% (HPLC)
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: water: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC₅₀ = 120 nM) vs. ADP-ribose (IC₅₀ = 120 mM). Also inhibits NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC₅₀ = 260 µM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration.

An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC₅₀ = 120 nM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration. Also acts as an inhibitor of NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC₅₀ = 260 µM). Note: 1 set = 5 x 60 µg.

Note: 1 set = 5 x 60 µg

Biochem/physiol Actions

Cell permeable: no

Primary Target
PARG

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 120 nM against poly(ADP-ribose) glycohydrolase (PARG)

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.

Other Notes

Vispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA97, 9886.
Slama, J.T., et al. 1995. J. Med. Chem.38, 389.
Slama, J.T., et al. 1995. J. Med. Chem.38, 4332.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable