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Chromolith® Performance RP-18 endcapped 100-4.6 HPLC column

Quality Level


PEEK column


suitable for USP L1

product line





1 ea of

extent of labeling

18% Carbon loading


200 bar pressure
45 °C max. temp.


HPLC: suitable
LC/MS: suitable
mass spectrometry (MS): suitable (High)

column L × I.D.

10 cm × 4.6 mm


monolithic silica

matrix active group

C18 bonding phase

pore size

13 nm mesoporosity
2 μm macroporosity

surface area

300 m2/g

operating pH range

2 - 7.5

separation technique

reversed phase

storage temp.

no temp limit

Related Categories

General description

All Chromolith® columns are made of monolithic silica with a characteristic bimodal pore structure. Chromolith 4.6 mm columns have macropores with 2 µm diamter, giving a column efficiency exceeding 80,000 plates/meter. The mesopores are 13 nm (130 Å), the surface modification is octadecylsilan with full end-capping.

Analysis Note

Appearance: conforms
Carbon content: 17,0 - 18,6 %
Pressure: ≤ 30 bar
stability testing: conforms
Performance (anthracene)
Theoretical Plates (N/m) (Anthracene): ≥ 80000
Capacity factor (Anthracene): 3,9 - 4,6
Tailing (USP): 0,90 - 1,60 %
separation factor (anthracene/progesterone): 1,95 - 2,35

Legal Information

Chromolith is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10-13 - German Storage Class 10 to 13

Certificate of Analysis

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Certificate of Quality

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Monolithic Silica with Bimodal Pore Structure

Monolithic silica HPLC columns enable high-throughput analysis at low back pressure without loss of separation efficiency or peak capacity.

Chromolith® HPLC and UHPLC columns

Chromolith® HPLC and UHPLC columns are made from monolithic silica with a bimodal pore structure using sol-gel technology.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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