MilliporeSigma
All Photos(1)

1.01728

Sigma-Aldrich

OSTEOSOFT®

mild decalcifier-solution for histology

Quality Level

form

liquid

color

dark red

pH

7.0-7.3 (20 °C in H2O)

density

1.10 g/mL at 20 °C

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

15-25°C

General description

This ready-to-use product, OSTEOSOFT® - mild decalcifier-solution for histology, has been specifically developed for human cell diagnostics in humans and is used for the demineralization and decalcification of bones, punched bone-marrow specimens, and other hard tissue of human origin.
Decalcification is necessary for optical microscopic examinations of hard tissue in routine histological procedures. For the decalcification of sensitive, calcium-containing tissues, such as iliac crest biopsies, OSTEOSOFT® can be used. Its formulation is based on EDTA. Its pendant, OSTEOMOLL®(Product number 1.01736), can be used for the decalcification of hard tissue such as teeth and bone as its formulation is based on formaldehyde and acetic acid. The amount of OSTEOSOFT®needed is dependent upon on the size, type and thickness of the material. Both solutions are color-coded, to distinguish them from each other, fixatives and solvents used in the histological laboratory. OSTEOSOFT® is color-coded yellow, OSTEOMOLL® is color-coded blue. Whereby OSTEOSOFT® preserves the antigen structures in the tissue, thus, an IHC analysis can be performed, OSTEOMOLL® will be used for tissues that are not destined for antibody analysis.
Both decalcifiers can be used for clinical diagnostic purposes and in laboratory accreditation processes as they are certified and registered as IVD and CE product. OSTEOSOFT® is used only once and fresh solution must be used for each tissue. The quantity of OSTEOSOFT® required is dependent on the size, type, and density of the respective material. For more details, please see instructions for use (IFU). The IFU can be downloaded from this webpage.

Legal Information

OSTEOMOLL is a registered trademark of Merck KGaA, Darmstadt, Germany
OSTEOSOFT is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

CorrosionHealth hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - STOT RE 2 Inhalation

Target Organs

Respiratory Tract

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Quality

Enter Lot Number to search for Certificate of Quality (COQ).

Related Content

Histology / Histopathology

Learn about the criticality of biological tissue staining for research and clinical pathology using standard and special stains and dyes.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service