03-0210-00

SMC^® Human pTau217 High Sensitivity Immunoassay Kit

kit sufficient for 96 wells

• Synonym(s): pTau217 Single Molecule Counting kit, pTau217 immunoassay kit, pTau217 ultra-sensitive immunoassay, phospho Tau 217 immunoassay kit
• UNSPSC Code: 12161503
• NACRES: NA.55

Properties

• description: 100uL (neat Serum, 1:2 diluted Plasma or 1:4 diluted CSF samples)
• species reactivity: human
• manufacturer/tradename: SMC^®
• assay range: intra-assay cv: ≤10%; (n=15); recovery range: 76-101%; (K2EDTA Plasma); recovery range: 77-94%; (CSF); recovery range: 82-126%; (Serum); sensitivity: 1.95 pg/mL; (lower limit of quantification); standard curve range: 0.49-500 pg/mL; inter-assay cv: ≤20%; (n=15)
• technique(s): single molecule counting: suitable
• input: serum; cerebrospinal fluid (CSF); plasma (K2EDTA)
• shipped in: wet ice
• storage temp.: 2-8°C

Description

General description

Tau protein is primarily a structural protein in neurons of the central nervous. Found as at least six different isoforms, these proteins are thought to provide structure, enable signaling, and regulate transport. In disease states, Tau proteins can become hyperphosphorylated and create tauopathies in the form of neurofibrillary or gliofibrillary tangles commonly associated with Alzheimer’s or Parkinson’s disease. Tau protein phosphorylated at threonine-217 is referred to as Phospho-Tau217 (pTau217). pTau217 is thought to be a promising marker for Alzheimer’s disease as it can be detected in serum or plasma and is strongly associated with physiological brain changes.


Research category : Neuroscience

Research sub-category : Alzheimer′s DiseaseAging, Nervous System, Neurodegenerative Diseases, Neuroscience

Specificity

This assay was tested for cross-reactivity with pTau181 and pTau231. No cross-reactivity was detected with either analyte.

Application

For SMC: used for ultrasensitivite quantification of Human pTau217 in human serum, plasma, and cerebrospinal fluid.

Features and Benefits

This SMC^® kit features:

• Accurate and reproducible performance on the state-of-the-art SMCxPRO® ultrasensitive immunoassay system.
• Compatiblity with automated liquid handling

Other Notes

SMC is a trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Legal Information

SMC is a registered trademark of Singulex

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302 + H312 + H332,H319,H360FD,H373,H412
• pcodes: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation
• target_organs: Respiratory Tract
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3