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M-021

Supelco

(±)-Methadone-D3 solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

DL-Methadone-d3 solution, DL-6-Dimethylamino-4,4-diphenyl-3-heptanone-1,1,1-d3 solution, DL-Methadone-(heptyl-1,1,1-d3) solution

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About This Item

Empirical Formula (Hill Notation):
C21D3H24NO
CAS Number:
Molecular Weight:
312.46
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

mass shift

M+3

storage temp.

2-8°C

SMILES string

[2H]C([2H])([2H])CC(=O)C(CC(C)N(C)C)(c1ccccc1)c2ccccc2

InChI

1S/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3/i1D3

InChI key

USSIQXCVUWKGNF-FIBGUPNXSA-N

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General description

A stable-labeled internal standard applicable for use in isotope dilution methods or quantitation of methadone levels by GC/MS or LC/MS in forensic analysis, urine drug testing, pain prescription monitoring or clinical toxicology applications. Methadone is a synthetic opioid used medically as an analgesic and as a maintenance anti-addictive for use in patients with opioid dependency. The drug is sold under several trade names such as Symoron, Dolophine®, Amidone, Methadose®, Physeptone, or Heptadon.

Application


  • Opioid pharmacokinetics research: (±)-Methadone-D3 solution is utilized in opioid pharmacokinetics research to track and analyze the metabolism of methadone, providing insights into its pharmacological properties and interaction dynamics (Beck et al., 2010).

  • MethaDonemetabolism study: As a deuterated methaDonesolution, it is critical for detailed studies on drug metabolism, aiding in the understanding of methadone′s biotransformation and its implications for therapeutic efficacy and safety (Anggård et al., 1979).

  • Mass spectrometry internal standard: Methadone-D3 serves as an internal standard in mass spectrometry, enhancing the precision of quantitative analyses in forensic and clinical toxicology (Johansen and Jensen, 2004).

  • Analytical research: Employed in analytical research, Methadone-D3 solution facilitates the development of advanced analytical methods for the detection and quantification of opioids in various biological matrices (Lucas et al., 2000).

  • Drug metabolism research: This solution is key in drug metabolism research, helping to identify the metabolic pathways and excretion profiles of methadone, which is crucial for developing effective dosing regimens and understanding drug interactions (Kintz et al., 1998).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Dolophine is a registered trademark of Roxane Laboratories, Inc.
Methadose is a registered trademark of Mallinckrodt Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup


Certificates of Analysis (COA)

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