B-023

BSTFA (with 1% TMCS)

kit of 10 × 1 mL, analytical standard, Cerilliant^®

• Synonym(s): N,O-Bis(trimethylsilyl)trifluoroacetamide, BSTFA
• Linear Formula: CF₃C[=NSi(CH₃)₃]OSi(CH₃)₃
• CAS Number: 25561-30-2
• Molecular Weight: 257.40
• Beilstein/REAXYS Number: 2050024
• MDL number: MFCD00008269
• UNSPSC Code: 41116107
• PubChem Substance ID: 329773102
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• reaction suitability: reagent type: derivatization reagent; reaction type: Acylations
• packaging: kit of 10 × 1 mL
• manufacturer/tradename: Cerilliant^®
• technique(s): gas chromatography (GC): suitable
• refractive index: n20/D 1.384 (lit.)
• bp: 45-50 °C/14 mmHg (lit.)
• density: 0.969 g/mL at 25 °C (lit.)
• application(s): forensics and toxicology
• format: neat
• storage temp.: −20°C
• SMILES string: C[Si](C)(C)O\C(=N\[Si](C)(C)C)C(F)(F)F
• InChI: 1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+
• InChI key: XCOBLONWWXQEBS-KPKJPENVSA-N

Description

Application

BSTFA (with 1% TMCS) may be used as a derivatizing agent in the following:

• Analysis of estrogenic compounds in water samples using gas chromatography coupled to mass spectrometry (GC-MS).
• Quantification of α-pyrrolidinovalerophenone (α-PVP) and its metabolites in urine samples using gas chromatography coupled to mass spectrometry (GC-MS).

Features and Benefits

• BSTFA is very versatile, reacting with a range of polar organic compounds and replacing active hydrogens with a −Si(CH₃)₃ (trimethylsilyl) group.
• Reacts rapidly and more completely than BSA.;
• TMCS increases the reactivity of BSTFA (or other silylation reagents).
• Amides and many secondary amines and hindered hydroxyls, incompletely derivatized by BSTFA alone, can be derivatized by adding 1-20% TMCS to BSTFA.
• Has good solvent properties and can function as a silylation reagent without additional solvents.
• Alternatively, the mixture is very soluble in most commonly used silylation solvents.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS02,GHS07
• signalword: Warning
• hcodes: H226 - H315 - H319
• pcodes: P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 75.2 °F - closed cup
• flash_point_c: 24.0 °C - closed cup