999992P

16:0 Diether PC

Avanti Research^™ - A Croda Brand 999992P, powder

• Synonym(s): 1,2-di-O-hexadecyl-sn-glycero-3-phosphocholine
• Empirical Formula (Hill Notation): C₄₀H₈₄NO₆P
• CAS Number: 36314-47-3
• Molecular Weight: 706.07
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• form: powder
• packaging: pkg of 1 × 10 mg (999992P-10mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 999992P
• lipid type: phospholipids; cardiolipins
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OCCCCCCCCCCCCCCCC)COCCCCCCCCCCCCCCCC)=O
• InChI: 1S/C40H84NO6P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-35-44-38-40(39-47-48(42,43)46-37-34-41(3,4)5)45-36-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h40H,6-39H2,1-5H3
• InChI key: MWTIGLPPQBNUFP-UHFFFAOYSA-N

Description

General description

16:0 Diether PC (phosphocholine) is a zwitterionic lipid having choline as the alcohol moiety, attached to the phosphate group. It has two hexadecane chains attached to the sn-1 and sn-2 positions of the glycerol backbone by ether bonds.

Application

16:0 Diether PC or 1,2-di-O-hexadecyl-sn-glycero-3-phosphocholine might be used:

• to study the miscibility and phase behavior of the cationic 1,2-dipalmitoyl-sn-glycero-3-ethylphosphocholine (EDPPC)
• in unilamellar vesicles to study glycolipid transfer protein (GLTP)-mediated transfer of anthrylvinyl-galactosylceramide (AV-GalCer) from different ether phospholipid matrices
• as a non-ladderane phosphocholine (PC) lipid reference sample in reversed-phase liquid chromatography (LC) method to separate PC lipids
• to prepare large phospholipid bicelles in order to determine the three-dimensional backbone structure of the transmembrane domain of Vpu from human immunodeficiency virus (HIV)-1 by solid-state nuclear magnetic resonance (NMR) spectroscopy

Biochem/physiol Actions

Ether glycerolipids serve as membrane molecules and cellular mediators. Ether linked phospholipids act as precursors for important signaling molecules. 16:0 Diether PC (phosphocholine) is known to interdigitate even in the absence of chemical inducers or pressure.

Packaging

5 mL Amber Glass Screw Cap Vial (999992P-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3