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COO/COA

14:0 PEG5000 PE

Name: 14:0 PEG5000 PE
Brand: AVANTI

Avanti Polar Lipids 880210P, powder

Synonym(s):

1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] (ammonium salt)

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About This Item

CAS Number:

474922-82-2

UNSPSC Code:

12352211

NACRES:

NA.25

form

powder

packaging

pkg of 1 × 25 mg (880210P-25mg)
pkg of 1 × 500 mg (880210P-500mg)

manufacturer/tradename

Avanti Polar Lipids 880210P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC([(OCH2CH2)113OCH3])=O)=O)(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O.[NH4+]

General description

14:0 PEG5000 PE, also known as 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000], (DMPE-PEG5000) is a polyethylene glycol (PEG)-modified lipid. Insertion of PEG-lipid conjugates into lipid bilayers decreases the rate of protein binding on the complex surface and thus, aids in formation of stabilized liposomes.

Application

14:0 PEG5000 PE or 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000], (DMPE-PEG5000) has been used to modify 1,4-dihydropyridine amphiphile DHP-12 complexes with DNA. It has also been used in preparation of polyethylene glycol (PEG)-ylated liposomes (PL).

Packaging

20 mL Clear Glass Screw Cap Vial (880210P-500mg)

5 mL Amber Glass Screw Cap Vial (880210P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Certificates of Analysis (COA)

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Dioleoyl phosphatidylethanolamine and PEG-lipid conjugates modify DNA delivery mediated by 1,4-dihydropyridine amphiphiles.

Zanna Hyvönen et al.

Journal of controlled release : official journal of the Controlled Release Society, 99(1), 177-190 (2004-09-03)

Complexes of amphiphilic cationic 1,4-dihydropyridines with DNA (lipoplexes) can be used for nonviral gene delivery. In order to achieve serum-resistant transfection system, DOPE and PEG-lipid conjugates were used to modify 1,4-dihydropyridine amphiphile DHP-12 complexes with DNA. The ability to bind

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