Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

860542P

Avanti

Lactosyl(β) Sphingosine (d18:1)

Avanti Research - A Croda Brand 860542P, powder

Synonym(s):

D-lactosyl-β1-1′-D-erythro-sphingosine

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C30H57NO12
CAS Number:
Molecular Weight:
623.77
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 5 mg (860542P-5mg)
pkg of 1 × 50 mg (860542P-50mg)

manufacturer/tradename

Avanti Research - A Croda Brand 860542P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@](N)([H])CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O[C@H](O2)[C@H](O)[C@@H](O)[C@H]([C@H]2CO)O

InChI

1S/C30H57NO12/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20(34)19(31)18-40-29-27(39)25(37)28(22(17-33)42-29)43-30-26(38)24(36)23(35)21(16-32)41-30/h14-15,19-30,32-39H,2-13,16-18,31H2,1H3/b15-14+/t19-,20+,21+,22+,23-,24-,25+,26+,27+,28+,29+,30-/m0/s1

InChI key

MQKSCOKUMZMISB-GPWKTZPCSA-N

General description

Lactosyl sphingosine is a glycosylsphingosine (Lyso-GSL), which is found in bovine brain white matter extract.

Application

Lactosyl(β) Sphingosine (d18:1) or D-lactosyl-β1-1′-D-erythro-sphingosine has been used as an internal standard for the quantification of psychosine using tandem mass spectrometry. It may be used to screen lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) or tight junction (TJ) permeability in epithelial tissue. It may also be used as a standard to determine the extent of recovery of lyso-neutral glycosphingolipids (lyso-n-GSLs) from the Sephadex column.

Biochem/physiol Actions

Lactosyl sphingosine exhibits better hemolytic activity than lysolecithin.

Packaging

5 mL Amber Glass Screw Cap Vial (860542P-50mg)
5 mL Amber Glass Screw Cap Vial (860542P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Dhimankrishna Ghosh et al.
Cell systems, 4(5), 516-529 (2017-04-04)
We present a systems strategy that facilitated the development of a molecular signature for glioblastoma (GBM), composed of 33 cell-surface transmembrane proteins. This molecular signature, GBMSig, was developed through the integration of cell-surface proteomics and transcriptomics from patient tumors in
Amy C Gross et al.
JCI insight, 3(16) (2018-08-24)
Osteosarcoma (OS), a malignant tumor of bone, kills through aggressive metastatic spread almost exclusively to the lung. Mechanisms driving this tropism for lung tissue remain unknown, though likely invoke specific interactions between tumor cells and other cells within the lung
Jacques Bodennec et al.
Journal of lipid research, 44(7), 1413-1419 (2003-05-06)
We describe a new method that permits quantification in the pmol to nmol range of three lyso-neutral glycosphingolipids (lyso-n-GSLs), glucosylsphingosine (GlcSph), galactosylsphingosine (GalSph), and lactosylsphingosine, in the same sample as neutral glycosphingolipids (n-GSLs). Lyso-n-GSLs and n-GSLs are initially obtained from
Richard Mair et al.
Cancer research, 78(18), 5408-5418 (2018-07-29)
13C MRI of hyperpolarized [1-13C]pyruvate metabolism has been used in oncology to detect disease, investigate disease progression, and monitor response to treatment with a view to guiding treatment in individual patients. This technique has translated to the clinic with initial
Heng-Jun Gao et al.
Journal of cancer research and clinical oncology, 141(7), 1151-1162 (2014-12-03)
Monocarboxylate transporter 4 (MCT4) is a critical component in the glycolytic metabolism of cancer cells, and is also important for malignant behavior. We investigated the expression profile of MCT4, its prognostic value in hepatocellular carcinoma (HCC) patients, its role in

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service