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840885P

Avanti

18:2 PA

Name: 18:2 PA
Brand: AVANTI

1,2-dilinoleoyl-sn-glycero-3-phosphate (sodium salt), powder

Synonym(s):

1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate (sodium salt); PA(18:2(9Z,12Z)/18:2(9Z,12Z))

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About This Item

Empirical Formula (Hill Notation):

C₃₉H₆₈O₈PNa

CAS Number:

322647-62-1

Molecular Weight:

718.92

UNSPSC Code:

51191904

NACRES:

NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 25 mg (840885P-25mg)

manufacturer/tradename

Avanti Research^™ - A Croda Brand 840885P

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O)=O)(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O.[Na+]

InChI

1S/C39H69O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h11-14,17-20,37H,3-10,15-16,21-36H2,1-2H3,(H2,42,43,44);/q;+1/p-1/b13-11-,14-12-,19-17-,20-18-;/t37-;/m1./s1

InChI key

UMYNPOZOTCNQKB-DKSSBCNHSA-M

General description

Phosphatidic acid (PA) is a precursor of lysophosphatidic acid (LPA) and is present in leafy vegetables.

Application

18:2 PA or 1,2-dilinoleoyl-sn-glycero-3-phosphate (sodium salt) might be used in saposin-derived lipid nanoparticle (SapNP) formation and in vacuolar mimic lipid (VML) proteoliposomes used for content-mixing assays.

Packaging

5 mL Clear Glass Sealed Ampule (840885P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid.

Mohamad Navab et al.

Journal of lipid research, 54(12), 3403-3418 (2013-10-03)

We recently reported that levels of unsaturated lysophosphatidic acid (LPA) in the small intestine significantly correlated with the extent of aortic atherosclerosis in LDL receptor-null (LDLR⁻/⁻) mice fed a Western diet (WD). Here we demonstrate that WD increases unsaturated (but

HOPS recognizes each SNARE, assembling ternary trans-complexes for rapid fusion upon engagement with the 4th SNARE.

Hongki Song et al.

eLife, 9 (2020-01-22)

Yeast vacuole fusion requires R-SNARE, Q-SNAREs, and HOPS. A HOPS SM-family subunit binds the R- and Qa-SNAREs. We now report that HOPS binds each of the four SNAREs. HOPS catalyzes fusion when the Q-SNAREs are not pre-assembled, ushering them into

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