840521P

18:1 Lysyl PG

1,2-dioleoyl-sn-glycero-3-[phospho-rac-(3-lysyl(1-glycerol))] (chloride salt), powder

• Synonym(s): Lysyl-DOPG
• Empirical Formula (Hill Notation): C₄₈H₉₃Cl₂N₂O₁₁P
• CAS Number: 1246303-07-0
• Molecular Weight: 976.14
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• assay: >99% (up to 15% acyl migration on lysine, TLC)
• form: powder
• packaging: pkg of 1 × 1 mg (840521P-1mg); pkg of 1 × 10 mg (840521P-10mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 840521P
• lipid type: phospholipids; bioactive lipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: OC(COC([C@@](CCCC[NH3+])([H])[NH3+])=O)COP(O)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O.[Cl-].[Cl-]

Description

General description

18:1 Lysyl PG/1,2-dioleoyl-sn-glycero-3-[phospho-rac-(3-lysyl(1-glycerol))] (lysyl-DOPG) is a synthetic phospholipid. It has a lysine group, added to the terminal glycerol of DOPG. Lysyl-phosphatidylglycerol (LPG), a membrane lipid is mainly seen in gram-positive bacteria. It is cationic phospholipid.

Application

18:1 Lysyl PG is suitable to prepare liposome solutions.

Biochem/physiol Actions

Lysyl-phosphatidylglycerol (lysyl-PG) in the cytoplasmic membranes of Staphylococcus is associated with improved resistance to antibiotics, like daptomycin and host defense antimicrobial peptides.

Packaging

5 mL Amber Glass Screw Cap Vial (840521P-1mg)

5 mL Clear Glass Sealed Ampule (840521P-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class: 11 - Combustible Solids