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810705P

Avanti

16-NBD-16:0 Coenzyme A

Avanti Research™ - A Croda Brand 810705P, powder

Synonym(s):

{N-[(7-nitro-2-1,3-benzoxadiazol-4-yl)-methyl]amino} palmitoyl Coenzyme A (ammonium salt)

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About This Item

Empirical Formula (Hill Notation):
C43H77N14O20P3S
CAS Number:
1367862-09-6
Molecular Weight:
1235.14
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (810705P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810705P

application(s)

lipidomics

lipid type

coenzymes

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@@](C(NCCC(NCCSC(CCCCCCCCCCCCCCCNC1=CC=C([N+]([O-])=O)C2=NON=C12)=O)=O)=O)(C(C)(COP([O-])(OP([O-])(OC[C@H]([C@H]3OP([O-])(O)=O)O[C@H]([C@@H]3O)N4C5=C(C(N)=NC=N5)N=C4)=O)=O)C)[H].[NH4+].[NH4+].[NH4+]

General description

NBD-palmitoyl-CoA ((N-[(7-nitro-2-1,3-benzoxadiazol-4-yl)-methyl]amino) palmitoyl Coenzyme A) is a fluorescent analog of palmitoyl-CoA.
Product can be used to fluorescently label palmitoylation sites on proteins.

Application

16-NBD-16:0 Coenzyme A ((N-[(7-nitro-2-1,3-benzoxadiazol-4-yl)-methyl]amino) palmitoyl Coenzyme A) has been used:
  • as a fluorescent substrate in fluorescent diacylglycerol acyltransferase (DGAT) assay
  • as a fluorescent analog to study the membrane translocation of lipids and to track palmitoyl-CoA uptake
  • as a component in wash buffer to measure autoacylation of the enzymes in palmitate transferase assay

Biochem/physiol Actions

NBD-palmitoyl-CoA ((N-[(7-nitro-2-1,3-benzoxadiazol-4-yl)-methyl]amino) palmitoyl Coenzyme A) can be used as an economical alternative to radioactive tracers.

Packaging

5 mL Amber Glass Screw Cap Vial (810705P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Maurine E Linder et al.
Biochemistry, 42(15), 4311-4320 (2003-04-16)
Since its discovery more than 30 years ago, protein palmitoylation has been shown to have a role in protein-membrane interactions, protein trafficking, and enzyme activity. Until recently, however, the molecular machinery that carries out reversible palmitoylation of proteins has been
S J Moench et al.
Biochemistry, 33(19), 5783-5790 (1994-05-17)
Two tandem cysteine residues in the carboxyl-terminal region of rhodopsin have been shown to be covalently linked to palmitate via thioester bonds (Ovchinnikov, Y. A., et al. (1988) FEBS Lett. 230, 1-5). We have synthesized a fluorescent analogue of palmitoyl
Xiaochao Wei et al.
Cell host & microbe, 11(2), 140-152 (2012-02-22)
The intestinal mucus barrier prevents pathogen invasion and maintains host-microbiota homeostasis. We show that fatty acid synthase (FAS), an insulin-responsive enzyme essential for de novo lipogenesis, helps maintain the mucus barrier by regulating Mucin 2, the dominant mucin in the
Pamela J McFie et al.
Journal of lipid research, 52(9), 1760-1764 (2011-06-10)
Triacylglycerols (TG) are the major storage form of energy in eukaryotic organisms and are synthesized primarily by acyl CoA:1,2-diacylglycerol acyltransferase (DGAT) enzymes. In vitro DGAT activity has previously been quantified by measuring the incorporation of either radiolabeled fatty acyl CoA
Raffaello Verardi et al.
Structure (London, England : 1993), 25(9), 1337-1347 (2017-08-02)
DHHC enzymes catalyze palmitoylation, a major post-translational modification that regulates a number of key cellular processes. There are up to 24 DHHCs in mammals and hundreds of substrate proteins that get palmitoylated. However, how DHHC enzymes engage with their substrates
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