QBD10505

Azido-dPEG^®₁₂-NHS ester

• Synonym(s): Polyethylene glycol
• Empirical Formula (Hill Notation): C₃₁H₅₆N₄O₁₆
• Molecular Weight: 740.79
• MDL number: MFCD13184947
• UNSPSC Code: 12352108
• PubChem Substance ID: 329823933
• NACRES: NA.22

Properties

• assay: >90%
• form: solid or viscous liquid
• reaction suitability: reaction type: click chemistry; reagent type: cross-linking reagent; reaction type: click chemistry
• polymer architecture: shape: linear; functionality: heterobifunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])ON1C(CCC1=O)=O

Description

Features and Benefits

The azido-dPEG^®₁₂-NHS ester contains an azide function on one end of a single molecular weight dPEG^® spacer (47.2 Å) and NHS ester group on the other end of the spacer. The dPEG^® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. N-hydroxysuccinimide (NHS) ester readily reacts with amines in aqueous solution or organic solvent. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable