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Key Documents

K6625

Sigma-Aldrich

2-Ketohexanoic acid sodium salt

97.0-103.0%

Synonym(s):

α-Ketocaproic acid sodium salt, 2-Ketocaproic acid sodium salt

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About This Item

Linear Formula:
C6H9O3Na
CAS Number:
Molecular Weight:
152.12
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

97.0-103.0%

form

powder

mp

240 °C (dec.) (lit.)

storage temp.

2-8°C

SMILES string

[Na].CCCCC(=O)C(O)=O

InChI

1S/C6H10O3.Na/c1-2-3-4-5(7)6(8)9;/h2-4H2,1H3,(H,8,9);/q;+1/p-1

InChI key

WDCARDDLMCHULC-UHFFFAOYSA-M

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pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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S Lenzen et al.
The Journal of biological chemistry, 257(12), 6631-6633 (1982-06-25)
2-Ketocaproate and 2-ketoisocaproate were equally potent insulin secretagogues. The insulin secretory potency of L-leucine was less than half of that of the keto acids and L-norleucine did not induce any insulin release by isolated islets and by the perfused pancreas
S A Metz
The Journal of pharmacology and experimental therapeutics, 238(3), 809-818 (1986-09-01)
Activation of an islet phospholipase A2 may contribute to glucose-induced insulin release. In order to simulate the accumulation of the resultant hydrolytic products (arachidonic acid, AA; its lipoxygenase-derived oxygenation product 12-hydroxyeicosatetraenoic acid; and lysophospholipids) without many of the other concomitants
M U Javed et al.
Journal of enzyme inhibition, 10(3), 187-193 (1996-01-01)
An LDH isoenzyme was purified to homogeneity from uromastix testes and its inhibition spectrum towards known LDH isoenzyme inhibitors studied. Platinum compounds inhibited the enzyme in the forward reaction (pyruvate-->lactate) only, n-hexanediol and colchicine showed no inhibition and gossypol acetic
W J Malaisse
Diabete & metabolisme, 9(4), 313-320 (1983-12-01)
Insulin release evoked by nutrient secretagogues invariably coincides with an increase in the catabolism of exogenous and/or endogenous nutrients in pancreatic islet cells, resulting in an increased generation rate of reducing equivalents and ATP, and an increase in O2 consumption.
S Nissen et al.
Analytical biochemistry, 188(1), 17-19 (1990-07-01)
A method for measuring the branched chain hydroxy acid beta-hydroxy-beta-methyl butyrate (HMB, a product of leucine catabolism) has been described. A [2H6]HMB internal standard was added to plasma and standards, and samples were extracted with diethyl ether, backextracted into neutral

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