F3401

2-Fluoroaniline

≥99%

• Synonym(s): 1-Amino-2-fluorobenzene
• Linear Formula: FC₆H₄NH₂
• CAS Number: 348-54-9
• Molecular Weight: 111.12
• Beilstein/REAXYS Number: 1524219
• EC Number: 206-478-9
• MDL number: MFCD00007642
• UNSPSC Code: 12352116
• PubChem Substance ID: 24894844
• NACRES: NA.25

Properties

• Quality Level: 100
• assay: ≥99%
• refractive index: n20/D 1.544 (lit.)
• bp: 182-183 °C (lit.)
• mp: −29 °C (lit.)
• density: 1.151 g/mL at 25 °C (lit.)
• SMILES string: Nc1ccccc1F
• InChI: 1S/C6H6FN/c7-5-3-1-2-4-6(5)8/h1-4H,8H2
• InChI key: FTZQXOJYPFINKJ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

The metabolism and excretion of the xenobiotic compound 2-fluoroaniline is important due to human exposure in manufacturing. It is found to be very efficiently metabolized, primarily by 4-hydroxylation with subsequent sulfate or glucuronide formation. N-Acetylation is also observed. At least 80% of the dose is excreted in the urine within 24 hr. 2-Fluoroaniline exerts its nephrotoxic effect through 4-hyroxylation and subsequent p-benzoquinonimine formation.

Safety Information

• pictograms: GHS02,GHS08,GHS05,GHS07,GHS09
• signalword: Danger
• hcodes: H226,H302,H314,H373,H410
• pcodes: P210 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1C - STOT RE 2
• target_organs: Blood,hematopoietic system
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 140.0 °F - closed cup
• flash_point_c: 60 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter