B80100

2-Bromopyridine

99%

• Synonym(s): β-Bromopyridine, 2-Pyridyl bromide, Pyridin-2-yl bromide, o-Bromopyridine
• Empirical Formula (Hill Notation): C₅H₄BrN
• CAS Number: 109-04-6
• Molecular Weight: 158.00
• Beilstein/REAXYS Number: 105789
• EC Number: 203-641-6
• MDL number: MFCD00006219
• UNSPSC Code: 12352100
• PubChem Substance ID: 24892038
• NACRES: NA.22

Properties

• Quality Level: 200
• assay: 99%
• form: liquid
• refractive index: n20/D 1.572 (lit.)
• bp: 192-194 °C (lit.)
• density: 1.657 g/mL at 25 °C (lit.)
• SMILES string: Brc1ccccn1
• InChI: 1S/C5H4BrN/c6-5-3-1-2-4-7-5/h1-4H
• InChI key: IMRWILPUOVGIMU-UHFFFAOYSA-N

Description

General description

2-Bromopyridine is an organic compound that is widely used as a building block in organic synthesis. It is also used as intermediate for the synthesis of Pyridine derivatives.

Application

2-Bromopyridine can be used as:

• A building block in the formation of C−N bond by various cross coupling reactions.
• A reactant in Negishi cross-coupling reaction with aryl halides catalyzed by palladium.
• A reactant in the synthesis of 2′-pyridyldifluoroacetate with ethyl bromodifluoroacetate in presence of copper as a catalyst.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H310,H315,H319,H335
• pcodes: P261 - P262 - P280 - P301 + P310 - P302 + P352 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: 195.1 °F - closed cup
• flash_point_c: 90.6 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter