A59654

5-Aminoindole

97%

• Synonym(s): 5-Indolamine, NSC 61452
• Empirical Formula (Hill Notation): C₈H₈N₂
• CAS Number: 5192-03-0
• Molecular Weight: 132.16
• Beilstein/REAXYS Number: 112348
• EC Number: 225-977-2
• MDL number: MFCD00005679
• UNSPSC Code: 12352100
• PubChem Substance ID: 24891044
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 97%
• form: crystals
• mp: 131-133 °C (dec.) (lit.)
• SMILES string: Nc1ccc2[nH]ccc2c1
• InChI: 1S/C8H8N2/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5,10H,9H2
• InChI key: ZCBIFHNDZBSCEP-UHFFFAOYSA-N

Description

Application

Reactant for preparation of:

• Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP
• Cytotoxic and antimitotic agents
• Insulin-like growth factor 1 receptor inhibitors
• Antitumoral agents
• Factor Xa inhibitor
• Potential antivascular agents
• Gli1-mediated transcription in the Hedgehog pathway
• Inhibitors of receptor tyrosine kinase with antiangiogenic effects
• PKCθ inhibitors
• HIV protease inhibitors

Safety Information

• pictograms: GHS06,GHS09
• signalword: Danger
• hcodes: H302,H311,H319,H400
• pcodes: P264 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves